Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06390787
Status:
COMPLETED
Last Update Posted:
2024-04-30
First Post:
2024-04-21
Brief Title:
The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics
Sponsor:
University of Baghdad
Organization:
University of Baghdad
Study Overview
Official Title:
Enhancing Antiemetic Efficacy A Randomized Trial of Vitamin B6 and Metoclopramide Combination Therapy Versus Traditional Regimens
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study investigates the effectiveness of combining vitamin B6 pyridoxine and metoclopramide compared to standard antiemetic treatments for managing nausea and vomiting Through a prospective randomized controlled trial involving adult patients with diverse causes of nausea and vomiting we aim to evaluate the frequency severity and tolerability of the B6 and metoclopramide combination By elucidating its comparative efficacy against established antiemetics this research seeks to provide evidence-based guidance for clinicians in selecting optimal treatment regimens tailored to individual patient needs ultimately enhancing the management of nausea and vomiting across various medical conditions
Detailed Description:
Title Investigating the Efficacy of B6 and Metoclopramide Combination Versus Alternative Antiemetics A Clinical Trial Proposal
Introduction
Nausea and vomiting are common symptoms across various medical conditions and can significantly impact patients quality of life and treatment outcomes While several antiemetic medications exist finding the most effective regimen remains a clinical challenge This proposal aims to investigate the efficacy of a combination therapy comprising vitamin B6 pyridoxine and metoclopramide compared to other antiemetics in managing nausea and vomiting
Rationale
Both vitamin B6 and metoclopramide have shown antiemetic properties through different mechanisms of action However the comparative efficacy of this combination therapy against other standard antiemetics remains largely unexplored Understanding the relative effectiveness of this combination could provide valuable insights into optimizing antiemetic strategies particularly in patients with chemotherapy-induced nausea and vomiting CINV postoperative nausea and vomiting PONV and other related conditions
Objectives
This prospective randomized controlled trial aims to evaluate the efficacy of B6 and metoclopramide combination therapy compared to alternative antiemetic regimens in reducing the frequency and severity of nausea and vomiting episodes in adult patients Additionally the study seeks to assess the safety profile and tolerability of the combination therapy
Conclusion
By elucidating the comparative efficacy of B6 and metoclopramide combination therapy this study endeavors to contribute to evidence-based decision-making in the management of nausea and vomiting The findings could potentially guide clinicians in selecting the most appropriate antiemetic regimen tailored to individual patient needs ultimately improving patient outcomes and quality of life
Introduction
Nausea and vomiting are common symptoms across various medical conditions and can significantly impact patients quality of life and treatment outcomes While several antiemetic medications exist finding the most effective regimen remains a clinical challenge This proposal aims to investigate the efficacy of a combination therapy comprising vitamin B6 pyridoxine and metoclopramide compared to other antiemetics in managing nausea and vomiting
Rationale
Both vitamin B6 and metoclopramide have shown antiemetic properties through different mechanisms of action However the comparative efficacy of this combination therapy against other standard antiemetics remains largely unexplored Understanding the relative effectiveness of this combination could provide valuable insights into optimizing antiemetic strategies particularly in patients with chemotherapy-induced nausea and vomiting CINV postoperative nausea and vomiting PONV and other related conditions
Objectives
This prospective randomized controlled trial aims to evaluate the efficacy of B6 and metoclopramide combination therapy compared to alternative antiemetic regimens in reducing the frequency and severity of nausea and vomiting episodes in adult patients Additionally the study seeks to assess the safety profile and tolerability of the combination therapy
Conclusion
By elucidating the comparative efficacy of B6 and metoclopramide combination therapy this study endeavors to contribute to evidence-based decision-making in the management of nausea and vomiting The findings could potentially guide clinicians in selecting the most appropriate antiemetic regimen tailored to individual patient needs ultimately improving patient outcomes and quality of life
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None