Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06396117
Status:
COMPLETED
Last Update Posted:
2024-05-02
First Post:
2024-04-29
Brief Title:
Relationship Between Anogenital Distance Serum AMH and mTESE in Klinefelter Syndrome
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Relationship Between Anogenital Distance and Serum AMH and mTESE Associated With or Without Klinefelter Syndrome
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
KS
Brief Summary:
Azoospermia the absence of sperm in the ejaculate affects approximately 1 of males and 15 of infertile men Non-obstructive azoospermia NOA accounts for 60 of azoospermic patients who rely solely on testicular sperm extraction TESE surgery for sperm harvesting While conventional TESE cTESE and microdissection TESE mTESE are preferred methods the lack of predictive biomarkers for successful sperm retrieval SR renders treatment unnecessary for many NOA males However research suggests that anti-Mullerian hormone AMH and anogenital distance AGD may serve as predictors of positive SR at mTESE in NOA males AGD a marker of fetal androgen disruption and adult outcomes may also assess male reproductive potential by predicting normal genital growth and sperm creation A cross-sectional study found a positive correlation between AGD and total sperm count concentration and motility in infertile men aged 25-38 providing valuable prognostic insights for azoospermic men
Detailed Description:
Azoospermia which is defined as the lack of spermatozoa in the ejaculate is a condition that affects around one percent of males and fifteen percent of men who are infertile Sixty percent of azoospermic patients are affected by non-obstructive azoospermia often known as NOA
To harvest sperm for assisted reproductive technology ART this subset of men has no other choice except to undergo testicular sperm extraction TESE surgery
Conventional TESE cTESE and microdissection TESE mTESE are the most preferred procedures in terms of sperm retrieval SR rates and the decrease of damage caused by excision Studies have revealed varying percentages of positive SR ranging from thirty percent to sixty percent
This treatment is not necessary for a significant number of NOA boys because there are no biomarkers or procedures that are clinically acceptable that can predict a positive SR score at mTESE
According to earlier research anti-mullerian hormone AMH which is a homodimeric glycoprotein belonging to the family of transforming growth factor-b has the potential to predict either a positive or negative significant difference SR at mTESE in iNOA Throughout the course of development Sertoli cells SCs secrete Amyloid-beta AMH in order to regress the Mullerian ducts and ensure that male sex differentiation occurs AMH levels drop significantly when the development of puberty in males and the maturation of SCs occurs It has been suggested that this hormone which is solely produced by spermatocytes in males can be used as an indirect marker of spermatogenesis maturation of spermatocytes and immaturity of the prepubertal testes
A noninvasive method known as anogenital distance has recently been applied for the purpose of predicting and diagnosing disorders There are two different measurements of the anogenital distance AGD for both men and women AGD is a marker that indicates fetal androgen dysregulation as well as negative effects in adulthood AGD is a unique method that can be used to evaluate the reproductive potential of males because it has the capacity to predict normal male genital growth and the production of sperm It may also assist medical professionals in providing prognostic information to men who are azoospermic
AGD AS was found to have a positive correlation with total sperm count concentration and motility in a cross-sectional study where the participants were infertile men between the ages of 25 and 38
To harvest sperm for assisted reproductive technology ART this subset of men has no other choice except to undergo testicular sperm extraction TESE surgery
Conventional TESE cTESE and microdissection TESE mTESE are the most preferred procedures in terms of sperm retrieval SR rates and the decrease of damage caused by excision Studies have revealed varying percentages of positive SR ranging from thirty percent to sixty percent
This treatment is not necessary for a significant number of NOA boys because there are no biomarkers or procedures that are clinically acceptable that can predict a positive SR score at mTESE
According to earlier research anti-mullerian hormone AMH which is a homodimeric glycoprotein belonging to the family of transforming growth factor-b has the potential to predict either a positive or negative significant difference SR at mTESE in iNOA Throughout the course of development Sertoli cells SCs secrete Amyloid-beta AMH in order to regress the Mullerian ducts and ensure that male sex differentiation occurs AMH levels drop significantly when the development of puberty in males and the maturation of SCs occurs It has been suggested that this hormone which is solely produced by spermatocytes in males can be used as an indirect marker of spermatogenesis maturation of spermatocytes and immaturity of the prepubertal testes
A noninvasive method known as anogenital distance has recently been applied for the purpose of predicting and diagnosing disorders There are two different measurements of the anogenital distance AGD for both men and women AGD is a marker that indicates fetal androgen dysregulation as well as negative effects in adulthood AGD is a unique method that can be used to evaluate the reproductive potential of males because it has the capacity to predict normal male genital growth and the production of sperm It may also assist medical professionals in providing prognostic information to men who are azoospermic
AGD AS was found to have a positive correlation with total sperm count concentration and motility in a cross-sectional study where the participants were infertile men between the ages of 25 and 38
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None