Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06396910
Status:
COMPLETED
Last Update Posted:
2024-05-02
First Post:
2024-04-30
Brief Title:
TB and Sarcoidosis Granuloma
Sponsor:
Karolinska Institutet
Organization:
Karolinska Institutet
Study Overview
Official Title:
Immune Maping of Tuberculosis and Sarcoidosis Granuloma
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tuberculosis TB and sarcoidosis are both granulomatous diseases Here we compared the immunological micro-environments of granulomas from TB and sarcoidosis patients using in situ sequencing ISS transcriptomic analysis and multiplexed immunolabelling of tissue sections
Detailed Description:
Tuberculosis TB and sarcoidosis are diseases that are characterized by the formation of inflammatory structures called granulomas TB is caused by infection with the bacteria Mycobacterium tuberculosis while sarcoidosis is a an inflammatory disease of unknown ethiology We hypothesize that the localization of immune molecules in granulomas determines the the course of TB and sarcoidosis using in situ sequencing a spatial transcriptomic technology and immunolabelling in biopsies from patients In the project we aim to answer the following questions 1 How does the immune landscape differ in different TB granulomas withwithout necrosis different histology 2 How does the immune landscape differ in acute Lofgrens syndrome and chronic non-Lofgrens syndrome sarcoidosis samples 3 How does the immune landscape differ in histologically similar granulomas from TB and sarcoidosis patients We will use in situ sequencing that can identify the exact location of 65 specific immune markers in the lung at the same time thereby correlating defined immune landscapes with the histology bacterial content and disease type
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None