Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06393140
Status:
RECRUITING
Last Update Posted:
2024-05-01
First Post:
2024-04-25
Brief Title:
The Study on the Mechanism of Radiotherapy-elicited Immune Response
Sponsor:
Fudan University
Organization:
Fudan University
Study Overview
Official Title:
The Study on the Mechanism of Radiotherapy-elicited Immune Response
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Radiotherapy plays an important role in multidisciplinary treatment of esophageal cancer Data from many laboratories indicate that local radiation produces systemic immune-mediated antitumour and potentially antimetastatic effects Additionally the combination of local radiotherapy and immune-modulation can augment local tumour control and cause distant abscopal antitumour effects through increased tumour-antigen release and antigen-presenting cell APC cross-presentation improved dendritic-cell DC function and enhanced T cell priming The generation of an effective antitumor immune response requires the presentation of tumor antigens to naïve CD8 cells in tumor-draining lymph nodes TDLN Tumor-draining lymph nodes however are often subject to the immunosuppressive activity of tumor-derived factors such as cytokines and other bioactive molecules from tumor cells and their associated leukocytes in the primary tumor site that contribute to the overriding of effective rejection mechanisms Thus in TDLN a T cell tolerance rather than a T cell activation often occurs thereby preventing immune attack and facilitating local tumor progression
Detailed Description:
In this study the investigators collect clinical and biological evidence to interpret the impact of radiotherapy on tumor regression and immunity and identify key molecular features and immune landscape patterns to characterize patients sensitiveresistant to radiotherapy and define the dynamic changes occurring in TME and lymph node after radiotherapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None