Ignite Creation Date:
2024-05-05 @ 7:03 PM
Last Modification Date:
2024-10-26 @ 9:42 AM
Study NCT ID:
NCT00599560
Status:
COMPLETED
Last Update Posted:
2016-03-29
First Post:
2008-01-10
Brief Title:
Vasopressin and V2 Receptor in Menieres Disease
Sponsor:
Osaka University
Organization:
Osaka University
Study Overview
Official Title:
Vasopressin and V2 Receptor in Menieres Disease
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Summary Some of sicknesses are well known to be provoked by inadequate adaptation to physical andor psychogenic stress in their daily life Menieres disease is also a common inner ear disease accompanied with vertigo hearing loss and tinnitus especially in civilized people under stressed life style Its oto-pathology was firstly revealed in 1938 to be inner ear endolymphatic hydrops through the temporal bone study To elucidate the neuroscientific relationship between stress and inner ear we examined plasma vasopressin the anti-diuretic stress hormone and its receptor V2R in the endolymphatic sac the inner ear endo-organ for endolymph absorption in Menieres patients
Detailed Description:
Methods Between 1998 and 2006 we enrolled and assigned 105 intractable Menieres patients to examine plasma vasopressin during remission of vertigo attacks controls 30 patients with chronic otitis media Using the real-time PCR method we examined V2R mRNA expression in the endolymphatic sac in 12 patients controls 6 patients with acoustic neurinoma By means of cell culture and cyclic AMP assay we also examined cyclic AMP activity in the endolymphatic sac in 3 patients controls 3 patients with acoustic neurinoma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Osaka Univ School of Medicine | None | None | None |