Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06395051
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-01
First Post:
2024-04-29
Brief Title:
Effects of Ketone Monoesters on Brain Function
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
Acute Effects of Ketone Monoester Supplementation on Brain Function in Older Men With Overweight
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Disturbances in brain insulin-sensitivity are not only observed in obesity and type 2 diabetes T2D but also during brain aging and in dementia Ketone monoester supplements may improve brain insulin-sensitivity which can be quantified by measuring the gray-matter cerebral blood flow CBF response to intranasally administered insulin We hypothesize that acute ketone monoester supplementation increases regional brain vascular function and insulin-sensitivity thereby improving cognitive performance and appetite control The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on regional brain vascular function and insulin-sensitivity as quantified by the non-invasive gold standard magnetic resonance imaging MRI-perfusion method Arterial Spin Labelling ASL The CBF response to intranasal insulin is a robust and sensitive physiological marker of brain insulin-sensitivity Secondary objectives are to investigate effects on cognitive performance as assessed with a neuropsychological test battery and appetite control as quantified by functional MRI fMRI with visual food cues
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None