Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06398834
Status:
COMPLETED
Last Update Posted:
2024-05-06
First Post:
2024-04-23
Brief Title:
Esketamine and Butorphanol for Post-Lobectomy Pain
Sponsor:
Second Peoples Hospital of Hefei City
Organization:
Second Peoples Hospital of Hefei City
Study Overview
Official Title:
Effect of Esketamine Combined With Butorphanol on Pain Management Following Video-assisted Lobectomy
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Post-thoracotomy pain syndrome PTPS affects respiratory function hindering sputum clearance and ventilation and represents a significant complication of thoracic surgery The analgesic effect of esketamine combined with butorphanol in PTPS is still unclear so this study focused on this aspect
Detailed Description:
Post-thoracotomy pain syndrome affects respiratory function hindering sputum clearance and ventilation and represents a significant complication of thoracic surgery Esketamine the left-handed optical isomer of racemic ketamine acts as an antagonist of the N-methyl-D-aspartate NMDA receptor reversing central sensitization and improving postoperative pain Butorphanol an opioid receptor agonist-antagonist can alleviate visceral pain reduce the risk of respiratory depression and decrease postoperative morphine consumption However research on the analgesic effects of esketamine combined with butorphanol in thoracoscopic surgery remains limited Therefore this study investigated the impact of esketamine combined with butorphanol on acute pain chronic pain and related side effects during the perioperative period in patients undergoing video-assisted lobectomy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None