Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06384287
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-25
First Post:
2024-04-03
Brief Title:
Peripheral Tissue Perfusion in Intensive Care
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Effects of Therapeutic Hemodynamic Interventions on Peripheral Perfusion in Intensive Care
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
INPPEREA
Brief Summary:
Tissue perfusion has been identified as an early prognosis factor in patients admitted to intensive care However little is known about the effects of different hemodynamic interventions performed in clinical routine on peripheral tissue perfusion
The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention fluid challenge vasopressor or inotropic drug
The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention fluid challenge vasopressor or inotropic drug
Detailed Description:
Sepsis is today a major cause of morbidity and mortality worldwide Septic shock the most serious manifestation of the infection affects 2 to 20 of intensive care patients Despite appropriate antibiotic therapy and improved resuscitation strategies based on early treatment volume expansion and rational use of vasopressors the mortality rate of shock states remains too high between 40 and 50
Over the past two decades great advances have been made in the understanding the pathophysiology of septic shock Microcirculatory abnormalities have been identified as the main cause of organ hypoperfusion and visceral failure leading to death In addition several studies in animals and humans have highlighted a discordance between systemic hemodynamic parameters and alterations of small vessels during shock suggesting that microvascular blood flow and tissue perfusion should be analyzed in patients with acute circulatory failure in association with blood pressure and cardiac output Capillary refill time CRT is an easy-to-use easy-to learn tool to evaluate peripheral tissue perfusion CRT is a strong predictive factor of organ failure severity and poor outcome in critically ill patients with sepsis A recent randomized trial reported promising results regarding the use of CRT to guide resuscitation However little is known about the impact of treatment on CRT The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention fluid challenge vasopressor or inotropic drug
Over the past two decades great advances have been made in the understanding the pathophysiology of septic shock Microcirculatory abnormalities have been identified as the main cause of organ hypoperfusion and visceral failure leading to death In addition several studies in animals and humans have highlighted a discordance between systemic hemodynamic parameters and alterations of small vessels during shock suggesting that microvascular blood flow and tissue perfusion should be analyzed in patients with acute circulatory failure in association with blood pressure and cardiac output Capillary refill time CRT is an easy-to-use easy-to learn tool to evaluate peripheral tissue perfusion CRT is a strong predictive factor of organ failure severity and poor outcome in critically ill patients with sepsis A recent randomized trial reported promising results regarding the use of CRT to guide resuscitation However little is known about the impact of treatment on CRT The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention fluid challenge vasopressor or inotropic drug
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None