Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06383923
Status:
RECRUITING
Last Update Posted:
2024-04-25
First Post:
2024-04-15
Brief Title:
Risk Factors Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section
Sponsor:
Peking University Third Hospital
Organization:
Peking University Third Hospital
Study Overview
Official Title:
Risk Factors Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean SectionA Prospective Cohort Study
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Identify the risk factors for Placenta accreta spectrum PAS disorders in women without prior caesarean section CS
2 Clarify the prognostic factors of the disease and explore individualized treatment options to improve the prognosis of patients with this type of disease
3 Use the cohorts biological sample database to conduct serology cytology and histology studies to explore the abnormal uterine immune microenvironment and the impact on uterine spiral artery remodeling in non-scar uterine-placenta accreta disease
2 Clarify the prognostic factors of the disease and explore individualized treatment options to improve the prognosis of patients with this type of disease
3 Use the cohorts biological sample database to conduct serology cytology and histology studies to explore the abnormal uterine immune microenvironment and the impact on uterine spiral artery remodeling in non-scar uterine-placenta accreta disease
Detailed Description:
The placenta accreta spectrum PAS is defined as abnormal placental trophoblast adherence with a wide range of myometrial invasion It is a serious pregnancy complication that can lead to severe postpartum hemorrhage which may necessitate hysterectomy and could ultimately lead to maternal deathPrevious studies have shown that women with the highest risk of PAS disorders are those with a prior cesarean section CS who present in the second trimester of pregnancy with any degree of placenta previa or low-lying placentaPAS patients without prior CS represent about one-third of the entire PAS populationThe strategy to identify at-risk patients without a prior CS has yet to be defined This may lead to under identification of PAS patients without prior CS and create a missed opportunity to plan the delivery and improve prognosis in these women Established risk factors distinct from prior CS delivery include in vitro fertilization IVF intrauterine implants endometritis uterine artery embolization manual placental removal uterine malformation adenomyosis submucosal fibroids smoking maternal weight maternal age parity and multifetal pregnancy Large clinical studies focusing on PAS disorders in women without prior CS are indeed scarceThis study aims to explore the risk factors and prognosis of PAS without a history of cesarean section and try to establish the prediction model
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None