Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06383338
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-22
First Post:
2024-03-21
Brief Title:
A Study Investigating the Change in Metabolism Phenotype in Paediatric Adolescent Young Adults With Hodgkin or Non-Hodgkin Lymphoma
Sponsor:
Murdoch Childrens Research Institute
Organization:
Murdoch Childrens Research Institute
Study Overview
Official Title:
A Prospective Feasibility Study Investigating PhEnoconversion of CYP3A4 CYP2C19 and CYP2D6 Genotype in Paediatric and Adolescent and Young Adult patientS With an acUte diagnosiS of Hodgkin or Non-Hodgkin Lymphoma
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PEGASUS
Brief Summary:
PEGASUS aims to test acceptability and feasibility of studying phenoconversion the change in metabolism phenotype using probe medications in a paediatric oncology patient population The study will be conducted in patients 6-25 years of age with Hodgkin lymphoma or non-Hodgkin lymphoma as exemplar cohort but with the understanding that cancer-directed and supportive care medicines of the CYP3A4 CYP2C19 and CYP2D6 metabolic pathways are commonly utilised for the treatment of many paediatric adolescent young adult and adult cancers
The study involves administration of the probe medication at timepoints which align with pre-determined hospital visits for the treatment of lymphoma and subsequent blood draws to measure the metabolism of the probe medications
The acceptability and feasibility of this study will inform future studies in phenoconversion within the paediatric cancer population to direct more personalised precision medicine
The study involves administration of the probe medication at timepoints which align with pre-determined hospital visits for the treatment of lymphoma and subsequent blood draws to measure the metabolism of the probe medications
The acceptability and feasibility of this study will inform future studies in phenoconversion within the paediatric cancer population to direct more personalised precision medicine
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None