Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06384014
Status:
RECRUITING
Last Update Posted:
2024-04-25
First Post:
2024-04-18
Brief Title:
Examining the Effect of Different Filling Techniques on Healing in Lesional Teeth
Sponsor:
TC Erciyes University
Organization:
TC Erciyes University
Study Overview
Official Title:
Comparison of the Effect of Orthograde and Retrograde Mineral Trioxide Aggregate Application on Healing After Apical Resection in Teeth With Periapical Lesions
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Microorganisms are an important factor in the development of periradicular diseases The goal of non-surgical endodontic treatment is to eliminate microorganisms and their byproducts from the root canal system and to create an effective barrier between the root canal system and surrounding tissues If there is no healing in the periradicular tissues after non-surgical endodontic treatment or if retreatment becomes impossible surgical endodontic treatment is required Apical resection is a surgical technique that involves removing the root tip of the tooth and closing the apical portion of the root canal system An ideal retrograde filling material should be non-toxic non-carcinogenic and biocompatible It must also have dimensional stability and sealing properties Amalgam glass ionomer cements and zinc oxide-eugenol based materials have been used for root end fillings in periapical surgery but the desired success was not achieved Today Mineral Trioxide Aggregate MTA is preferred as a retrograde filling material due to its superior sealing properties ability to harden in the presence of blood and moisture antibacterial effects biocompatibility and radiopacity
In the researchers study the effect of apical resection after orthograde canal filling and retrograde canal filling during apical resection on postoperative recovery will be compared In both canal filling techniques Sure-Seal Root MTA Sure Dent Corporation-Korea will be used as the filling material Sure-Seal Root MTA is a calcium silicate based paste that is typically pre-mixed and ready to apply exhibits excellent physical properties and does not show shrinkage during the curing process As the manufacturer states it is hydrophilic biocompatible has ideal setting and working time
Our faculty has piezosurgical ultrasonics Mectron Grassobbio BG Italy After the root tip resection is performed the retrograde cavity will be prepared with Woodpecker ultrasonic tips Guilin China compatible with this device In our study using these materials and devices a comparative analysis of the effects of different canal filling techniques on lesion healing and improvement in clinical symptoms will be made
In the researchers study the effect of apical resection after orthograde canal filling and retrograde canal filling during apical resection on postoperative recovery will be compared In both canal filling techniques Sure-Seal Root MTA Sure Dent Corporation-Korea will be used as the filling material Sure-Seal Root MTA is a calcium silicate based paste that is typically pre-mixed and ready to apply exhibits excellent physical properties and does not show shrinkage during the curing process As the manufacturer states it is hydrophilic biocompatible has ideal setting and working time
Our faculty has piezosurgical ultrasonics Mectron Grassobbio BG Italy After the root tip resection is performed the retrograde cavity will be prepared with Woodpecker ultrasonic tips Guilin China compatible with this device In our study using these materials and devices a comparative analysis of the effects of different canal filling techniques on lesion healing and improvement in clinical symptoms will be made
Detailed Description:
Periapical or periradicular lesions are barriers that restrict microorganisms and prevent their spread to surrounding tissues microorganisms cause periapical lesions either primary or secondary Apical infections if left untreated can follow two different paths First the infection can create a path inside or outside the mouth causing the pus to drain out Secondly infection within the canal It may reach the periapical tissues and create a cavity surrounded by polymorphonuclear leukocytes in the bone leading to the formation of inflammatory radicular cysts
Inflammatory radicular cysts IRCs are chronic lesions that occur after the development of periapical granulomas PGs PGs and IRCs are thought to follow pulp infections as an inflammatory process at the periapical level Although both conditions PG and IRC are clinically diagnosed as apical periodontitis AP they differ significantly histopathologically
The majority of apical cysts are asymptomatic and may develop insidiously by being discovered incidentally during a routine x-ray examination as a large periapical radiolucency covering the apex of one or more teeth By confirming that the lesion is a granuloma or cyst a more definitive diagnosis is reached by histopathological examination Although conventional radiographic methods cannot be used for the definitive diagnosis of periapical cysts larger round or oval well-circumscribed radiolucent images around the apex of the tooth are considered to be cystic lesions
When the infection in the canal is successfully treated apical cysts can regress by the apoptosis mechanism in the root canal without the need for surgical intervention Researchers stated that incorrect histopathological diagnosis in early studies created the false impression that radicular cysts were more common and that this methodological error led to the illusion that most cystic lesions in the periapex area healed after non-surgical root canal treatment In conclusion the authors suggested that true cysts may be less likely to heal with nonsurgical root canal treatment due to their inherently self-sustaining properties and may require surgical intervention Whether true cysts heal after non-surgical root canal treatment is still a major debate
Different retrograde canal filling materials have been tried in the literature but today Mineral Trioxide Aggregate MTA is most commonly used because it is more biocompatible and has a periapical healing-inducing effect MTA It is the first restorative material that allows cementum development and provides regeneration in periodontal ligament cells In addition histological sections taken from the periapical region of teeth with retrograde canal filling with MTA often showed new cementum formation not only on the resection surface but also directly on the MTA For this reason MTA is called bioactive material Properties of MTA such as biocompatibility sealing and the capacity to increase the regeneration of pulp and periradicular tissues It has increased the diversity of dental usage areas and clinical success rates and has become the focus of attention of clinicians with this innovative structure In comparative studies on retrograde filling materials MTA has demonstrated an excellent tissue response with almost no inflammatory component
There are few studies in the literature comparing the effects of two different canal filling techniques orthograde retrograde which are currently frequently used on postoperative recovery There is no study comparing the long-term postoperative radiographic and clinical improvement levels of using MTA with different application techniques in teeth with periapical lesions with an indication for apical resection The purpose of researchers planned study is to compare and evaluate the healing effect of orthograde MTA application followed by resection in teeth with large periapical lesions and retrograde MTA application during apical resection operation
Inflammatory radicular cysts IRCs are chronic lesions that occur after the development of periapical granulomas PGs PGs and IRCs are thought to follow pulp infections as an inflammatory process at the periapical level Although both conditions PG and IRC are clinically diagnosed as apical periodontitis AP they differ significantly histopathologically
The majority of apical cysts are asymptomatic and may develop insidiously by being discovered incidentally during a routine x-ray examination as a large periapical radiolucency covering the apex of one or more teeth By confirming that the lesion is a granuloma or cyst a more definitive diagnosis is reached by histopathological examination Although conventional radiographic methods cannot be used for the definitive diagnosis of periapical cysts larger round or oval well-circumscribed radiolucent images around the apex of the tooth are considered to be cystic lesions
When the infection in the canal is successfully treated apical cysts can regress by the apoptosis mechanism in the root canal without the need for surgical intervention Researchers stated that incorrect histopathological diagnosis in early studies created the false impression that radicular cysts were more common and that this methodological error led to the illusion that most cystic lesions in the periapex area healed after non-surgical root canal treatment In conclusion the authors suggested that true cysts may be less likely to heal with nonsurgical root canal treatment due to their inherently self-sustaining properties and may require surgical intervention Whether true cysts heal after non-surgical root canal treatment is still a major debate
Different retrograde canal filling materials have been tried in the literature but today Mineral Trioxide Aggregate MTA is most commonly used because it is more biocompatible and has a periapical healing-inducing effect MTA It is the first restorative material that allows cementum development and provides regeneration in periodontal ligament cells In addition histological sections taken from the periapical region of teeth with retrograde canal filling with MTA often showed new cementum formation not only on the resection surface but also directly on the MTA For this reason MTA is called bioactive material Properties of MTA such as biocompatibility sealing and the capacity to increase the regeneration of pulp and periradicular tissues It has increased the diversity of dental usage areas and clinical success rates and has become the focus of attention of clinicians with this innovative structure In comparative studies on retrograde filling materials MTA has demonstrated an excellent tissue response with almost no inflammatory component
There are few studies in the literature comparing the effects of two different canal filling techniques orthograde retrograde which are currently frequently used on postoperative recovery There is no study comparing the long-term postoperative radiographic and clinical improvement levels of using MTA with different application techniques in teeth with periapical lesions with an indication for apical resection The purpose of researchers planned study is to compare and evaluate the healing effect of orthograde MTA application followed by resection in teeth with large periapical lesions and retrograde MTA application during apical resection operation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None