Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06384040
Status:
RECRUITING
Last Update Posted:
2024-04-30
First Post:
2024-04-05
Brief Title:
Immuno-based Profiling of knEe OA Patients to Predict reSponse to Regenerative Treatment
Sponsor:
Istituto Clinico Humanitas
Organization:
Istituto Clinico Humanitas
Study Overview
Official Title:
Immuno-based Profiling of knEe OA Patients to Predict reSponse to Regenerative Treatment
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IMPRESA
Brief Summary:
Osteoarthritis OA is a highly prevalent degenerative musculoskeletal disease and a major cause of chronic disability worldwide Its multifactorial origin contributes to determine the heterogeneous phenotypes and one unmet need is the lack of biomarkers to predict the individual response Platelet-rich-plasma PRP injection is a minimally invasive autologous blood-derived approach for which we plan to define specific knee profiles predictive of response We will take advantage of a unique multidisciplinary approach aimed at analysing clinics imaging and biomarkers of associated with clinical response We will focus on inflammatory Wnt system IL1 pathway PTX3 and antioxidant primarily DPP3Keap1Nrf2 pathways We foresee that our results will allow a better allocation of immunomodulatory and regenerative therapies for a personalized approach in knee OA thus maximising the effectiveness of the healthcare allocation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None