Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06380062
Status:
COMPLETED
Last Update Posted:
2024-04-25
First Post:
2023-05-02
Brief Title:
Choline Metabolites in People With Prostate Cancer and Those With Benign Hyperplasia
Sponsor:
Universität des Saarlandes
Organization:
Universität des Saarlandes
Study Overview
Official Title:
Pre-operative Plasma Concentrations of Choline and Its Metabolites in People With Prostate Cancer Compared to Those With Benign Hyperplasia
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study was to investigate plasma concentrations of one-carbon metabolites and phospholipid classes in participants with primary prostate cancer and those with benign hyperplasia Moreover the metabolites were studied in relation to tumor grade and age
Detailed Description:
This observational study recruited participants with primary prostate cancer cases and those with benign hyperplasia controls before the surgery Data on the outcomes of the surgery including the results of the biopsy investigation were collected Blood samples were collected before the surgery in context of routine blood investigations Blood plasma samples collected on ethylenediaminetetraacetic acid EDTA were used to measure concentrations of free choline betaine dimethylglycine folate forms S-adenosylhomocysteine S-adenosylmethionine homocysteine cystathionine and methylmalonic acid MMA Data on serum concentrations of prostate specific antigen PSA and the tumor grade and classification Gleason Score system were collected The associations between the plasma concentrations of the metabolites and PSA or the Gleason score were studied The concentrations of the metabolic markers were compared between the cases and the controls according to the age of the participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None