Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06372444
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-19
First Post:
2024-03-25
Brief Title:
Mechanisms of Acute Kidney Injury in Severe Infections
Sponsor:
Uppsala University Hospital
Organization:
Uppsala University Hospital
Study Overview
Official Title:
Mechanisms of Acute Kidney Injury in Severe Infections
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PET-AKI
Brief Summary:
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography For marked water will be used for renal perfusion and a newly developed PET tracer molecule 11C-GW457427 with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations
Detailed Description:
To study renal perfusion and neutrophil-mediated inflammation 10 critically ill patients with sepsis and acute kidney injury AKI and 5 healthy volunteers as controls will be recruited and examined at one time with marked water followed by neutrophil elastase tracer At the same time a CT scan is performed for anatomy Plasma levels of inflammatory mediators will be measured Clinical data will be collected The endpoints are changes in renal perfusion and increased presence of neutrophil elastase in the renal parenchyma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None