Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06373055
Status:
RECRUITING
Last Update Posted:
2024-04-18
First Post:
2023-12-12
Brief Title:
Prediction of Therapeutic Response to Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer Patients Using Spatial Transcriptomics
Sponsor:
Yonsei University
Organization:
Yonsei University
Study Overview
Official Title:
Prediction of Therapeutic Response to Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer Patients Using Spatial Transcriptomics
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Although neoadjuvant chemotherapy in muscle-invasive bladder cancer has significantly improved oncological outcomes approximately 50 of patients do not respond to neoadjuvant chemotherapy which has adverse effects on patients by causing treatment toxicity and surgical delays Therefore treatment tailored specifically to the individual patient based on the genetic andor molecular profile of the patient is urgently needed Among patients scheduled for neoadjuvant chemotherapy the investigators should differentiate between patients who will be highly effective with neoadjuvant chemotherapy and those who will not and preferentially select other treatments including radical cystectomy in the patients with high probability of failure to neoadjuvant chemotherapy However there is no standard which patients would benefit from neoadjuvant chemotherapy This study plans to predict treatment response to neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer by analyzing genetic and molecular profiles of tumor tissues obtained through transurethral bladder tumor resection
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None