Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06370078
Status:
RECRUITING
Last Update Posted:
2024-06-06
First Post:
2024-04-12
Brief Title:
Effect of Early Administration of Albumin 20 Versus Crystalloid
Sponsor:
Egymedicalpedia
Organization:
Egymedicalpedia
Study Overview
Official Title:
Effect of Early Administration of Albumin 20 Versus Crystalloid During Resuscitation of Patient With Septic Shock a Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sepsis and septic shock are global health problems leading to a high mortality rate They are often associated with extremely low blood pressure and multiple organ dysfunctions which are the main causes of death in critically ill patients Fluid resuscitation is one of the most critical treatments for patients with sepsis and septic shock
An early administration of an appropriate fluid to patients is considered the most effective way to increase blood pressure improve tissue perfusion and save their lives Crystalloid fluids are a subset of intravenous solutions composed of mineral salts and other small water-soluble molecules including normal isotonic or hypertonic saline and various buffered solutions
An early administration of an appropriate fluid to patients is considered the most effective way to increase blood pressure improve tissue perfusion and save their lives Crystalloid fluids are a subset of intravenous solutions composed of mineral salts and other small water-soluble molecules including normal isotonic or hypertonic saline and various buffered solutions
Detailed Description:
Crystalloid fluids are a subset of intravenous solutions composed of mineral salts and other small water-soluble molecules including normal isotonic or hypertonic saline and various buffered solutions
Colloid solutions are composed of various amounts of substances for instance albumin hydroxyethyl starch dextran and gelatine Although the current international guidelines from the Surviving Sepsis Campaign recommend crystalloids to perform the initial resuscitation and the replacement with albumin on patients who require substantial amounts of crystalloids the choice of the best type of resuscitation fluids is still under debate
Albumin in addition to its oncotic functions has a variety of other properties including binding and transport of various endogenous molecules anti-inflammatory and anti-oxidative effects and modulation of nitric oxide metabolismThese properties are particularly relevant in critically ill patients especially in patients with sepsis
Colloid solutions are composed of various amounts of substances for instance albumin hydroxyethyl starch dextran and gelatine Although the current international guidelines from the Surviving Sepsis Campaign recommend crystalloids to perform the initial resuscitation and the replacement with albumin on patients who require substantial amounts of crystalloids the choice of the best type of resuscitation fluids is still under debate
Albumin in addition to its oncotic functions has a variety of other properties including binding and transport of various endogenous molecules anti-inflammatory and anti-oxidative effects and modulation of nitric oxide metabolismThese properties are particularly relevant in critically ill patients especially in patients with sepsis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None