Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06375889
Status:
RECRUITING
Last Update Posted:
2024-06-17
First Post:
2024-04-16
Brief Title:
Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
APICRASH
Brief Summary:
Aneurysmal subarachnoid haemorrhage is a complex pathology the pathophysiology of which is still imperfectly understood Its morbidity and mortality remain significant In addition to the damage sustained by the brain in the immediate aftermath of aneurysmal rupture which is inaccessible to life-saving treatment a significant proportion of lesions occur at a distance from the initial event Delayed cerebral ischaemia is one of the most morbid complications It combines an inflammatory pattern with vascular dysfunction and neuronal excitotoxicity leading to avoidable secondary neuronal loss
Vascular dysfunction is mediated by a loss of homeostasis between endothelial cells and figurative blood cells including platelets However the interrelationship between these elements and the precise chronology of the dysfunction remain imperfectly described to date
It therefore seems appropriate to propose temporal monitoring of platelet activation kinetics over time combined with concomitant collection of markers of endothelial damage in order to clarify the vascular chronobiology of this pathology
Vascular dysfunction is mediated by a loss of homeostasis between endothelial cells and figurative blood cells including platelets However the interrelationship between these elements and the precise chronology of the dysfunction remain imperfectly described to date
It therefore seems appropriate to propose temporal monitoring of platelet activation kinetics over time combined with concomitant collection of markers of endothelial damage in order to clarify the vascular chronobiology of this pathology
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2024-A00796-41 | OTHER | ID-RCB | None |