Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06372418
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-18
First Post:
2023-07-10
Brief Title:
Providing Breastfeeding Support After Discharge From Hospital to Improve Growth and Development of Malnourished Infants
Sponsor:
University of Oxford
Organization:
University of Oxford
Study Overview
Official Title:
Enhancing Growth and Development Among Malnourished Infants Recovering From a Serious Illness IBAMI-2
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IBAMI-2
Brief Summary:
The current guidelines used to manage malnutrition among infants aged below 6 months u6m recommend that infants admitted to hospital with malnutrition be supported to reestablish exclusive breastfeeding before discharge Studies have shown that reestablishing exclusive breastfeeding among infants being treated for acute malnutrition is possible However follow-up of the infants after discharge has revealed poor growth raising questions about what happens to infant feeding practices after discharge and whether providing breastfeeding support to mothers after discharge would help improve the recovery and growth of their infants
Providing a package of home-based care with breastfeeding support to mothers of infants u6m recovering from acute malnutrition has the potential to improve the retention of exclusive breastfeeding and lead to enhanced infant growth and survival To date no such post-discharge package of care is available in Kenya or other lower and meddle income countries LMICs The aim of this study is to apply participatory qualitative and quantitative approaches to develop and evaluate the impact of a post-discharge package of care on the growth and development of acutely ill malnourished infants after discharge from hospital
Providing a package of home-based care with breastfeeding support to mothers of infants u6m recovering from acute malnutrition has the potential to improve the retention of exclusive breastfeeding and lead to enhanced infant growth and survival To date no such post-discharge package of care is available in Kenya or other lower and meddle income countries LMICs The aim of this study is to apply participatory qualitative and quantitative approaches to develop and evaluate the impact of a post-discharge package of care on the growth and development of acutely ill malnourished infants after discharge from hospital
Detailed Description:
Globally acute malnutrition affects 85 million infants under 6 months of age u6m These malnourished infants u6m are at elevated risk of death during admission death after discharge from hospital and subsequent neurodevelopmental impairment The 2020 national guidelines for integrated management of acute malnutrition for infants and children IMAM recommend that for hospitalised malnourished infants u6m the treatment should focus on re-establishing exclusive breastfeeding EBF with discharge when consistent weight gain of 20gday is achieved on breastmilk alone In Kilifi a study to investigate the outcomes of effective guideline implementation employed breastfeeding peer supporters to facilitate re-establishing exclusive breastfeeding among sick hospitalized malnourished infants u6mThe study achieved 81 infants exclusive breastfeeding by discharge with 67 attaining the World health organization recommended growth velocity on breastmilk alone However when infants were followed up 6 weeks after discharge the criteria for full nutritional recovery weight adjusted for Length Z score WFL2 were generally not met Interviews with mothers breastfeeding peer supporters BFPS and health workers at discharge and 4 weeks after discharge suggested that BFPS were central in enabling mothers to achieve exclusive breastfeeding but that mothers found it challenging to maintain exclusive breastfeeding at home after discharge without on-going support This follow-on study will investigate the hypothesis that providing support during transition from hospital to home environment will help improve nutritional recovery among this vulnerable group of infants The study will take part in two phases Phase1 will use participatory and qualitative approaches to develop and pilot test a post-discharge breast-feeding support intervention BFSI Phase 2 will involve a randomized control trial to measure the impact of the intervention on growth EBF and neurodevelopmental outcomes of malnourished infants discharged from hospital following a serious illness
The primary outcome for the trial is growth weight gain assessed at age 6 months with additional follow up at 9 and 12 months of age to assess mortality morbidity and neurodevelopmental outcomes The results of the study will inform efforts to improve post-discharge management of recovering malnourished vulnerable infants u6m
The primary outcome for the trial is growth weight gain assessed at age 6 months with additional follow up at 9 and 12 months of age to assess mortality morbidity and neurodevelopmental outcomes The results of the study will inform efforts to improve post-discharge management of recovering malnourished vulnerable infants u6m
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None