Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06379126
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-23
First Post:
2024-04-17
Brief Title:
The Diagnostic and Prognostic Value of TAT PIC tPAIC and TM in Sepsis-induced Coagulopathy
Sponsor:
The First Hospital of Jilin University
Organization:
The First Hospital of Jilin University
Study Overview
Official Title:
The Diagnostic and Prognostic Value of Thrombin-Antithrombin ComplexTAT α2-plasmin Inhibitor-plasmin ComplexPIC Tissue Plasminogen Activator-inhibitor ComplextPAIC and ThrombomodulinTM in Sepsis-induced Coagulopathy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In order to evaluate the diagnostic and prognostic value of thrombin-antithrombin complexTAT α2-plasmin inhibitor-plasmin complexPIC tissue plasminogen activator-inhibitor complextPAIC and thrombomodulinTM in sepsis-induced coagulopathySIC hospitalized patients with sepsis were prospectively included Plasma TAT PIC tPAICTM levels within 24 h after sepsis diagnosis were detected by MCL60 chemiluminescence analyzer According to the SIC score 4 they were divided into SIC group and non-SIC group and ROC curve analysis was performed according to the biomarker test results
Detailed Description:
Thrombin-antithrombin complexTAT α2-plasmin inhibitor-plasmin complexPIC tissue plasminogen activator-inhibitor complextPAIC and thrombomodulinTM can evaluate vascular endothelial damage thrombin and plasminase activation and have clinical significance in early diagnosis of DIC thrombotic disease and monitoring of thrombolysis efficacy However whether these biomarkers can be used for early diagnosis of SIC is unclear
In order to evaluate the diagnostic value of TAT PIC tPAIC and TM in sepsis-induced coagulopathySIC hospitalized patients with sepsis were prospectively included Plasma TAT PIC tPAICTM levels within 24 h after sepsis diagnosis were detected by MCL60 chemiluminescence analyzer According to the SIC score 4 they were divided into SIC group and non-SIC group and receiver operator characteristicROC curve analysis was performed according to the biomarker test results The area under the curveAUC was used to determine whether TAT PIC tPAIC and TM could be used as biomarkers for SIC diagnosis If AUC is between 07 and 09 this indicator has diagnostic value
In order to evaluate the diagnostic value of TAT PIC tPAIC and TM in sepsis-induced coagulopathySIC hospitalized patients with sepsis were prospectively included Plasma TAT PIC tPAICTM levels within 24 h after sepsis diagnosis were detected by MCL60 chemiluminescence analyzer According to the SIC score 4 they were divided into SIC group and non-SIC group and receiver operator characteristicROC curve analysis was performed according to the biomarker test results The area under the curveAUC was used to determine whether TAT PIC tPAIC and TM could be used as biomarkers for SIC diagnosis If AUC is between 07 and 09 this indicator has diagnostic value
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None