Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06377657
Status:
COMPLETED
Last Update Posted:
2024-04-22
First Post:
2024-03-23
Brief Title:
Oxidative and Antioxidant Indices to HIIT and Aloe Vera Supplementation in Patients With T2DM
Sponsor:
University of Nis
Organization:
University of Nis
Study Overview
Official Title:
METRNL Response Plasma Oxidative and Antioxidant Indices to HIIT and Aloe Vera Supplementation in Patients With Diabetes Type 2
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Diabetes is a prevalent metabolic disease that leads to increased blood sugar levels due to insulin shortage or resistance Type 2 diabetes is often linked to obesity which can increase insulin resistance Meteorin-like protein METRNL is a new secreted protein that affects insulin sensitivity and has been found to be negatively related to serum glucose levels in people with diabetes
Oxidative stress in diabetics can stimulate the production of inflammatory mediators increasing the activity of the antioxidant system Aloe vera a widely used plant has been used for treating diabetes wound healing tumors and inflammatory bowel disease It has anti-inflammatory antioxidant neuroprotective antidepressant and memory-enhancing effects
Exercise can improve diabetic patients conditions by increasing the expression of GLUT4 protein and skeletal muscle High-intensity interval training has been shown to increase the expression of the METORIN gene in human subjects and decrease MDA in type 2 diabetic patients However no studies have examined the simultaneous effect of exercise and Aloe vera on diabetes indicators
The present study aims to investigate the response of METRNL and some oxidative and antioxidant plasma indicators to high-intensity interval training and Aloe vera supplementation in type 2 diabetic men The findings indicate that exercise and consumption of plants with anti-inflammatory and antioxidant properties can be effective in modulating the pathological effects of diabetes and increasing insulin sensitivity
Oxidative stress in diabetics can stimulate the production of inflammatory mediators increasing the activity of the antioxidant system Aloe vera a widely used plant has been used for treating diabetes wound healing tumors and inflammatory bowel disease It has anti-inflammatory antioxidant neuroprotective antidepressant and memory-enhancing effects
Exercise can improve diabetic patients conditions by increasing the expression of GLUT4 protein and skeletal muscle High-intensity interval training has been shown to increase the expression of the METORIN gene in human subjects and decrease MDA in type 2 diabetic patients However no studies have examined the simultaneous effect of exercise and Aloe vera on diabetes indicators
The present study aims to investigate the response of METRNL and some oxidative and antioxidant plasma indicators to high-intensity interval training and Aloe vera supplementation in type 2 diabetic men The findings indicate that exercise and consumption of plants with anti-inflammatory and antioxidant properties can be effective in modulating the pathological effects of diabetes and increasing insulin sensitivity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None