Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06370975
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-17
First Post:
2024-04-13
Brief Title:
Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Effect of 3 Hypertonic Saline Resuscitation on Lactate and Its Comparison With Ringers Lactated Solution and 09 Normal Saline in Traumatic Injury Patients A Prospective Randomized Control Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to investigate the effect of 3 hypertonic saline resuscitation on lactate clearance in comparison to ringers lactated solution and 09 normal saline in traumatic injury patients
Also to provide insights into the optimal fluid resuscitation strategy for traumatic injury patients
Also to provide insights into the optimal fluid resuscitation strategy for traumatic injury patients
Detailed Description:
Traumatic injuries considered as important leading causes of morbidity and mortality worldwide haemorrhagic shock is a common and critical complication Fluid resuscitation is a crucial step in managing traumatic injury patients and the choice of resuscitation fluid can significantly impact patient outcomes In the context of trauma rapid and effective resuscitation is essential to prevent irreversible cellular dysfunction and multi-organ failure
Lactate is a key indicator of tissue perfusion and oxygenation in trauma patients with faster clearance rates associated with improved outcomes There is growing interest in the use of hypertonic saline for resuscitation in traumatic injury patients as it may lead to faster lactate clearance compared to traditional crystalloid solutions such as ringers lactated solution and 09 normal saline Additionally it has been suggested that hypertonic saline may improve microvascular blood flow and tissue oxygenation which can aid in lactate clearance Ringers lactated solution is commonly used for fluid resuscitation in trauma patients providing volume expansion and buffering capacity Furthermore 09 normal saline is widely utilized in clinical practice but concerns regarding its potential to induce hyperchloremic acidosis have been raised Given the varied physiological effects of these resuscitative fluids it is imperative to conduct a robust randomized controlled trial to elucidate their respective impacts on lactate clearance and overall outcomes in traumatic injury patients Such a comprehensive trial will facilitate evidence-based decision-making and potentially optimize resuscitation strategies in the acute care of trauma patients ultimately improving survival and reducing the burden of trauma-related morbidity and mortality To our knowledge there is few studies discussing the differences between the use of 3 hypertonic ringers lactated and 09 normal salines in urgent resuscitation of trauma patients
Lactate is a key indicator of tissue perfusion and oxygenation in trauma patients with faster clearance rates associated with improved outcomes There is growing interest in the use of hypertonic saline for resuscitation in traumatic injury patients as it may lead to faster lactate clearance compared to traditional crystalloid solutions such as ringers lactated solution and 09 normal saline Additionally it has been suggested that hypertonic saline may improve microvascular blood flow and tissue oxygenation which can aid in lactate clearance Ringers lactated solution is commonly used for fluid resuscitation in trauma patients providing volume expansion and buffering capacity Furthermore 09 normal saline is widely utilized in clinical practice but concerns regarding its potential to induce hyperchloremic acidosis have been raised Given the varied physiological effects of these resuscitative fluids it is imperative to conduct a robust randomized controlled trial to elucidate their respective impacts on lactate clearance and overall outcomes in traumatic injury patients Such a comprehensive trial will facilitate evidence-based decision-making and potentially optimize resuscitation strategies in the acute care of trauma patients ultimately improving survival and reducing the burden of trauma-related morbidity and mortality To our knowledge there is few studies discussing the differences between the use of 3 hypertonic ringers lactated and 09 normal salines in urgent resuscitation of trauma patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None