Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06378515
Status:
RECRUITING
Last Update Posted:
2024-04-22
First Post:
2024-04-17
Brief Title:
Physical Activity Sleep and Brain Health Based on the Glymphatic System
Sponsor:
University of Valencia
Organization:
University of Valencia
Study Overview
Official Title:
Physical Activity Sleep and Brain Health Based on the Glymphatic System
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is aiming to analyze the impact of physical activity on neurohydrodynamics and glymphatic activity on young adults This study is designed as a multicenter descriptive observational study with information collection at two different times before performing a short exercise routine and during its performance using a wearable wireless device Glymphometer
Detailed Description:
The glymphatic system was discovered in 2013 as a brain mechanism for the elimination of protein waste in the central nervous system Scientific findings indicate that an abnormality in this system involves a slow accumulation of protein waste neurological inflammation leaks in the blood-brain barrier and finally neuronal degeneration due to the progressive loss of neurons in the central nervous system Brain fluid dynamics particularly those related to cerebrospinal fluid have been shown to play an important role in brain health and the progression of neurodegenerative diseases The Glymphometer is a device that allows the evaluation of brain health in a novel way as it allows the monitoring of brain fluid dynamics and could allow early detection of abnormalities in the glymphatic system This technology makes it easy to monitor brain health and allows you to set actions for a healthier lifestyle It also makes it possible to monitor the effectiveness of emerging therapies to avoid or reduce the risk of neurological diseases In the long term this could allow for more cost-effective prevention tools This device has been used in numerous research projects and is also closely related to other projects funded by the European Commission currently underway such as Neurodegenerative Disease Research JPND The data generated by these wearable devices will also be useful for healthcare systems as such data can be collected in other situations such as during sleep exercise or at work These devices will be used both at the diagnostic level and also to monitor the impact of neurological therapies allowing for more personalized treatments The Glymphometer has previously been used in studies that have looked at the impact of stress on brain health Physical activity and exercise are other lifestyle factors that have an influence on brain health as shown by preclinical studies and recent reviews on the glymphatic system and have been proposed as preventive therapy and treatment for dementia due to their impact on the glymphatic system The existing literature shows that lifestyle factors such as sleep physical activity or stress can be highly relevant to brain health but there is not enough scientific evidence based on continuous measurements of how they affect it
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None