Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06379152
Status:
RECRUITING
Last Update Posted:
2024-04-23
First Post:
2024-04-15
Brief Title:
Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction
Sponsor:
Chongqing Medical University
Organization:
Chongqing Medical University
Study Overview
Official Title:
Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Factors influencing the prognosis of patients with heart failure with preserved ejection fraction HFpEF have been extensively studied Previous studies have found that elevated serum total bilirubin levels are associated with cardiac death heart failure readmission and all-cause mortality in patients with chronic heart failure However the relationship between direct bilirubin and prognosis in patients with HFpEF is unclear
Detailed Description:
Patients with heart failure with preserved ejection fraction account for approximately 50 of all heart failure patients have approximately 14 hospitalisations per year and an annual mortality rate of approximately 15 Till now there have no definitively proven therapies that can reduce their morbidity and mortality HFpEF Patients have a poor prognosis The current study found that the prognosis of patients with HFpEF may be related to the heterogeneity of the disease its various phenotypes and multifactorial pathophysiology which has not been fully elucidated The current study found that bilirubin is a risk factor for adverse outcomes of various HFpEF-related complications but the relationship between direct bilirubin and prognosis of HFpEF has not been reported Therefore the investigators speculate that direct bilirubin is a predictor of prognosis of HFpEF patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None