Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06372093
Status:
COMPLETED
Last Update Posted:
2024-04-17
First Post:
2024-01-22
Brief Title:
Evaluation of Bilirubin Measurements in Newborns From Smartphone Digital Images in a Population in Botswana
Sponsor:
Picterus AS
Organization:
Picterus AS
Study Overview
Official Title:
Evaluation of Bilirubin Measurements in Newborns From Smartphone Digital Images in a Population in Botswana
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The general objective of this study is to evaluate the accuracy of a novel smartphone application for jaundice screening Picterus Jaundice Pro in a population with high melanin content in the skin
The specific objectives for this study are
i To assess the correlation between bilirubin level measurements obtained by Picterus Jaundice Pro with Total Serum Bilirubin TSB and TcB in newborns with high melanin content in the skin
ii To determine the accuracy of Picterus Jaundice Pro in newborns with high melanin content in the skin
The specific objectives for this study are
i To assess the correlation between bilirubin level measurements obtained by Picterus Jaundice Pro with Total Serum Bilirubin TSB and TcB in newborns with high melanin content in the skin
ii To determine the accuracy of Picterus Jaundice Pro in newborns with high melanin content in the skin
Detailed Description:
The goal for this project is to demonstrate that the Picterus Jaundice Pro screening method can be used to identify children with severe neonatal jaundice independent of skin color Thus providing a cheaper patient-friendly and more readily available method of neonatal jaundice detection The long-term goal is that with the implementation of the app the identification of newborns with severe jaundice will be improved and thus referred at an earlier stage for diagnostics and treatment
The study will be a cross-sectional study with quantitative methods of data collection
The study population will comprise 150 newborns from the Neonatal Unit and the maternity ward at Princess Marina Hospital
Parents to newborns with and without signs of jaundice will be asked to participate
Following informed consent background data such as birth weight age on examination gestational age and type of feeding will be obtained Gestational age will be based on ultrasound determination and the last normal menstruation period LNMP The skin type of the infant will be classified according to the newborn Neomars scale score
Transcutaneous bilirubin measurements will be performed over the sternum of the infant A Dräger Jaundice Meter JM-105 will be used in this study Skin reflectance will be measured using a portable Konica Minolta spectrophotometer CM-700d
A validated smartphone with Picterus Jaundice Pro will be used to collect digital images of skin of the infant chest together with the Picterus calibration card After all the images are obtained a unique ID will be displayed on the smartphone This ID will be recorded on the case report forms and later used to pair clinical data and digital images
A blood sample to determine TSB will be obtained within 60 minutes of obtaining the images and processed at the Department of clinical biochemistry in the hospital laboratory
After completion of the study the bilirubin measurement from Picterus Jaundice Pro will be determined and compared to the TSB and TCB measurements using the Pearson correlation coefficient Sub-analysis for the different skin colors will be performed Systematic over- or under-estimation of bilirubin levels will be evaluated using Bland-Altman plots Sensitivity and specificity analysis will be calculated for different cut-off values ROC analysis
The study will be a cross-sectional study with quantitative methods of data collection
The study population will comprise 150 newborns from the Neonatal Unit and the maternity ward at Princess Marina Hospital
Parents to newborns with and without signs of jaundice will be asked to participate
Following informed consent background data such as birth weight age on examination gestational age and type of feeding will be obtained Gestational age will be based on ultrasound determination and the last normal menstruation period LNMP The skin type of the infant will be classified according to the newborn Neomars scale score
Transcutaneous bilirubin measurements will be performed over the sternum of the infant A Dräger Jaundice Meter JM-105 will be used in this study Skin reflectance will be measured using a portable Konica Minolta spectrophotometer CM-700d
A validated smartphone with Picterus Jaundice Pro will be used to collect digital images of skin of the infant chest together with the Picterus calibration card After all the images are obtained a unique ID will be displayed on the smartphone This ID will be recorded on the case report forms and later used to pair clinical data and digital images
A blood sample to determine TSB will be obtained within 60 minutes of obtaining the images and processed at the Department of clinical biochemistry in the hospital laboratory
After completion of the study the bilirubin measurement from Picterus Jaundice Pro will be determined and compared to the TSB and TCB measurements using the Pearson correlation coefficient Sub-analysis for the different skin colors will be performed Systematic over- or under-estimation of bilirubin levels will be evaluated using Bland-Altman plots Sensitivity and specificity analysis will be calculated for different cut-off values ROC analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None