Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06371001
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-17
First Post:
2024-04-13
Brief Title:
Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical Complex
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Detect prevalence of Helicobacter pylori infection in chronic kidney diseased patient admitted to Luxor medical complex and possible role of Helicobacter pylori in pathogenesis of chronic kidney diseased patient of unknown etiology
Detailed Description:
Helicobacter Pylori bacteria is the main pathogenic organism that settles on the gastric mucosa of more than half the human population around the world with more prominence in the developing countries H Pylori had been found to be the main factor in acute and chronic gastritis peptic ulcer diseases and in most cases gastric malignancy Beside to some extra gastro-intestinal diseases Such as cardiac pulmonary renal and hematological diseases
Another study showed a significant higher proteinuria in H Pylori infected patients compared to non-infected individuals Helicobacter pylori is a gram-negative bacterium infecting both children and adults It is the most common human chronic infection causing gastrointestinal diseases such as gastric malignancies gastritis and ulcerative diseases H pylori can also be involved in other non gastrointestinal infections such as diabetes and metabolic syndrome heart disease hematologic disorders cancer and chronic kidney disease CKD as well as chronic renal failure CRF
Some chronic renal failure patients who have received hemodialysis for long periods complained of gastrointestinal troubles It has been postulated that high urea concentration makes the gastric mucosa of these patients more susceptible to H pylori colonization Previous observations in different countries reported the prevalence of H pylori infection among patients with CRF ranging between 20 and 60 and H pylori infection can contribute to progressive renal dysfunction resulting in CKD development In patients without established gastric dysfunction the presence of H pylori infection was associated with increased risk for Chronic kidney dusease however patients with both atrophic gastritis AG and Helcobacter pylori infection appeared to be at decreased risk for Chronic kidney disease compared with control participants
For the H pylori-positive patients with peptic ulcer H pylori infection may be a risk factor resulting in kidney damage and H pylori eradication probably benefits to kidney damage relief and chronic kidney disease prevention
Another study showed a significant higher proteinuria in H Pylori infected patients compared to non-infected individuals Helicobacter pylori is a gram-negative bacterium infecting both children and adults It is the most common human chronic infection causing gastrointestinal diseases such as gastric malignancies gastritis and ulcerative diseases H pylori can also be involved in other non gastrointestinal infections such as diabetes and metabolic syndrome heart disease hematologic disorders cancer and chronic kidney disease CKD as well as chronic renal failure CRF
Some chronic renal failure patients who have received hemodialysis for long periods complained of gastrointestinal troubles It has been postulated that high urea concentration makes the gastric mucosa of these patients more susceptible to H pylori colonization Previous observations in different countries reported the prevalence of H pylori infection among patients with CRF ranging between 20 and 60 and H pylori infection can contribute to progressive renal dysfunction resulting in CKD development In patients without established gastric dysfunction the presence of H pylori infection was associated with increased risk for Chronic kidney dusease however patients with both atrophic gastritis AG and Helcobacter pylori infection appeared to be at decreased risk for Chronic kidney disease compared with control participants
For the H pylori-positive patients with peptic ulcer H pylori infection may be a risk factor resulting in kidney damage and H pylori eradication probably benefits to kidney damage relief and chronic kidney disease prevention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None