Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06371495
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-17
First Post:
2024-04-14
Brief Title:
Statins Role in Acute Ischemic Stroke
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Statins in Acute Ischemic StrokeRole of Statins in Reperfusion in Acute Stroke
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
observation
Brief Summary:
Strokes is amajor cause of death and disabilities in different countried
Detailed Description:
Stroke is a major cause of mortality and disability in modern societies Statins are effective medications in decreasing cardiovascular events through lipid lowering and pleiotropic effects Ischemic stroke is burdened with a high morbidity and mortality in our society However there are few effective and largely available therapies for this devastating disease In additon to advancing acute reperfusion therapies there is a need to develop treatments aimed to promote repair and regeneration of brain tissue damaged by ischemia neurorecovery123 Therapeutic angiogenesis and vasculogenesis represent novel approaches of regenerative medicine that may help in the cure of patients with acute ischemic stroke Translation of our knowledge about these processes from the bench to bedside is still underway Although angiogenesis the sprouting of new blood vessels from pre-existing vascular structures is likely to contribute to neurorepair the finality of the angiogenic response in acute ischemic stroke has not been fully elucidated The first therapeutic approach to angiogenesis after ischemic stroke would be the modulation of the endogenous angiogenic response In this setting early instauration of physical activity statins and peroxisome proliferator-activated receptor-γ agonists may enhance angiogenesis and neuroregeneration Statins have been shown to improve the functional outcome of patients after an ischemic stroke We hypothesized that daily statin intake improves functional outcome after an acute ischemic stroke 45678 Duplex sonography is the best noninvasive modality for investigation of possible carotid artery stenosis to evaluate the intema media thickness of carotid artery in patients of acute ischemic stroke before and after receiving high dose of statins to evaluate its effectiveness in management and appropriate dose of statins 91011121314
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None