Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06377956
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-23
First Post:
2024-04-17
Brief Title:
The Associations Between Gut Length Gut Microbiota and Food Assimilation
Sponsor:
Shenzhen Institute of Advanced Technology Chinese Academy of Sciences
Organization:
Shenzhen Institute of Advanced Technology Chinese Academy of Sciences
Study Overview
Official Title:
Associations Between Gut Length Gut Microbiota and Food Assimilation Efficiency of Healthy Individuals
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this observational study is to explore the relationships between gut length the microbiota and food energy assimilation rates in humans
Detailed Description:
The focus of this work is to characterize the relationship between gut length gut microbiota and food energy assimilation rate in healthy individuals
The gut will be scanned using Magnetic Resonance Imaging MRI to calculate gut length To obtain clearer images volunteers will be asked to drink 115 sachet of He Shuang polyethylene glycol electrolyte powder molecular weight of 4000 and injected Raceanisodamine Hydrochloride Injection with 10 mg by intramuscular Volunteers will be asked to drink He Shuang which dissolved in 115L of water for the purpose of filling the intestines As a contrast to improve imaging during scanning
Volunteers will be given the experimental meal which providing enough energy for volunteers to eat as much as they want Feces and urine will be collected to calculate the assimilation rate To more accurately label the food edible polyethylene glycol with a molecular weight of 3350PEG3350 is used Provides 15g of PEG3350 per day to be used with meals PEG3350 reaches a steady state in the intestinal tract for 3 days Food will be provided for seven days during the test period the first three days are aimed at stabilizing the PEG3350 in the intestine and the samples to be counted are mainly collected in the last four days Food assimilation rate and metabolizable energy will be calculated for the 4-day
The gut microbiota will be analyzed by metagenomics and metabolomics This study combines metabolomics analysis techniques with imaging and physiological measurements to focus on the potential relationship between gut length and food absorption rates Researchers anticipate recruiting up to 100 healthy volunteers body mass index 185
The gut will be scanned using Magnetic Resonance Imaging MRI to calculate gut length To obtain clearer images volunteers will be asked to drink 115 sachet of He Shuang polyethylene glycol electrolyte powder molecular weight of 4000 and injected Raceanisodamine Hydrochloride Injection with 10 mg by intramuscular Volunteers will be asked to drink He Shuang which dissolved in 115L of water for the purpose of filling the intestines As a contrast to improve imaging during scanning
Volunteers will be given the experimental meal which providing enough energy for volunteers to eat as much as they want Feces and urine will be collected to calculate the assimilation rate To more accurately label the food edible polyethylene glycol with a molecular weight of 3350PEG3350 is used Provides 15g of PEG3350 per day to be used with meals PEG3350 reaches a steady state in the intestinal tract for 3 days Food will be provided for seven days during the test period the first three days are aimed at stabilizing the PEG3350 in the intestine and the samples to be counted are mainly collected in the last four days Food assimilation rate and metabolizable energy will be calculated for the 4-day
The gut microbiota will be analyzed by metagenomics and metabolomics This study combines metabolomics analysis techniques with imaging and physiological measurements to focus on the potential relationship between gut length and food absorption rates Researchers anticipate recruiting up to 100 healthy volunteers body mass index 185
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None