Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06376500
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-19
First Post:
2024-04-08
Brief Title:
Effects of TDCS for Enhancing Cognitive Function in Individuals with Persistent Post-Concussion Syndrome
Sponsor:
The Hong Kong Polytechnic University
Organization:
The Hong Kong Polytechnic University
Study Overview
Official Title:
Effects of Transcranial Direct Current Stimulation for Enhancing Cognitive Function in Individuals with Persistent Post-Concussion Syndrome a Pilot FMRI1H-MRS Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Globally 10 million new traumatic brain injury TBI cases are estimated annually with mild traumatic brain injury mTBI accounting for 75-90 of all TBI cases It is estimated that 40-80 of individuals with mTBI may experience the post-concussion syndrome PCS which is characterized by a range of physical cognitive and emotional symptoms Although the underlying basis of cognitive dysfunction of patients with persistent PCS remains to be clarified converging evidence shows that the clinical symptoms is underpinned by abnormal neural information processing as a result of axonal injury due to mTBI Recent studies have demonstrated abnormalities in both structural and functional cortical connectivity and a loss of cortical excitability-inhibitory EI balance after TBI Yet there is no consensus for treating chronic symptoms of concussion and PCS remains a chronic and highly disabling condition One potential treatment option is transcranial direct current stimulation tDCS a non-invasive brain stimulation technique that has been shown to modify behavior by enhancing connectivity between targeted brain areas However research on the therapeutic effect of tDCS on PCS symptoms is limited and the neurologic mechanisms underlying its effects are not well understood The proposed study aims to address these knowledge gaps by examining the effects of tDCS on the central nervous system function in patients with PCS with a specific focus on functional cortical connectivity and cognitive functions such as processing speed and executive function The study also aims to add value to existing evidence by potentially opening new directions for designing intervention programs for the treatment of PCS after mTBI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None