Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06362408
Status:
COMPLETED
Last Update Posted:
2024-04-12
First Post:
2024-04-09
Brief Title:
Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients
Sponsor:
Chinese PLA General Hospital
Organization:
Chinese PLA General Hospital
Study Overview
Official Title:
Effect of Intraoperative Use of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients Undergoing Non-cardiac Surgery
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chinas aging population is causing an increase in the number of senior persons undergoing surgery More and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients
Dexmedetomidine DEX is an alpha-2 adrenergic agonist that works by inhibiting norepinephrine releasing renaline which reduces inflammation and thus plays a protective role in the central nervous system DEX has the potential to prevent and treat postoperative anxiety and depression in elderly patients undergoing non-cardiac surgery
Further exploration of evidence for evidence-based medicine is needed Based on the above research background this hypothesis is proposed in elderly patients undergoing noncardiac surgery intraoperative DEX is associated with a reduction in short-term postoperative mental disorders and a reduction in long-term postoperative mortality
Dexmedetomidine DEX is an alpha-2 adrenergic agonist that works by inhibiting norepinephrine releasing renaline which reduces inflammation and thus plays a protective role in the central nervous system DEX has the potential to prevent and treat postoperative anxiety and depression in elderly patients undergoing non-cardiac surgery
Further exploration of evidence for evidence-based medicine is needed Based on the above research background this hypothesis is proposed in elderly patients undergoing noncardiac surgery intraoperative DEX is associated with a reduction in short-term postoperative mental disorders and a reduction in long-term postoperative mortality
Detailed Description:
Studies have suggested that continuous infusion of low-dose DEX during the night after surgery can significantly reduce the incidence of delirium alleviate pain and improve subjective sleep quality
However it is currently unclear whether choosing DEX during anesthesia has any impact on mortality and mental disorders in older patients undergoing non-cardiac surgery
Therefore we utilized prospective research data from 7 centers in China to explore the relationship between intraoperative use of DEX and postoperative 12-month mortality and mental disorders Propensity score-matching PSM and Inverse probability of treatment weighting IPTW were conducted and subgroup analyses were also applied
However it is currently unclear whether choosing DEX during anesthesia has any impact on mortality and mental disorders in older patients undergoing non-cardiac surgery
Therefore we utilized prospective research data from 7 centers in China to explore the relationship between intraoperative use of DEX and postoperative 12-month mortality and mental disorders Propensity score-matching PSM and Inverse probability of treatment weighting IPTW were conducted and subgroup analyses were also applied
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None