Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06368297
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-16
First Post:
2024-02-26
Brief Title:
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in OverweightObese Adults
Sponsor:
University of Macau
Organization:
University of Macau
Study Overview
Official Title:
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in OverweightObese Adults A Neurophysiological and Resting Functional Magnetic Resonance Study rfMRI
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity followed by a second 2-week intervention study aimed to compare the effect of a ketogenic diet versus ketone ester supplementation on motor cortex plasticity resting brain function and structure and metabolic and neuroendocrine responses
Detailed Description:
The study initially makes a bold attempt to explore whether the ketone supplementation would induce improvements in the overweight obese populations brain health via altering motor cortex plasticity brain function and structure and metabolic and neuroendocrine pathways The studys aims include
assessing changes in brain plasticity associated with excessive body weight andor obesity
evaluating the potential of ketone monoester supplementation in enhancing brain plasticity
evaluating the potential of ketone monoester supplementation in correcting impaired brain plasticity due to excessive body weight
evaluating the impact of short-term ketogenic dieting and ketone monoester supplementation on brain plasticity
investigating structural and functional brain adaptations to short-term ketogenic dieting and ketone supplementation
assessing the relationship between changes in brain plasticity and the brains structural and functional adaptations and changes in circulating levels of brain-derived neurotrophic factors and key central acting hormones ie insulin and leptin due to ketogenic dieting and ketone monoester supplementation
assessing changes in brain plasticity associated with excessive body weight andor obesity
evaluating the potential of ketone monoester supplementation in enhancing brain plasticity
evaluating the potential of ketone monoester supplementation in correcting impaired brain plasticity due to excessive body weight
evaluating the impact of short-term ketogenic dieting and ketone monoester supplementation on brain plasticity
investigating structural and functional brain adaptations to short-term ketogenic dieting and ketone supplementation
assessing the relationship between changes in brain plasticity and the brains structural and functional adaptations and changes in circulating levels of brain-derived neurotrophic factors and key central acting hormones ie insulin and leptin due to ketogenic dieting and ketone monoester supplementation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None