Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06361407
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-11
First Post:
2024-04-03
Brief Title:
Sensory and Cognitive Predictions and Their Disruptions in Schizophrenia
Sponsor:
Centre Psychothérapique de Nancy
Organization:
Centre Psychothérapique de Nancy
Study Overview
Official Title:
Sensory and Cognitive Predictions and Their Disruptions in Schizophrenia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SensoSchiz
Brief Summary:
Disturbances in the sense of self and time could play an important role in the development of psychotic symptoms Previous work has shown that patients have difficulty preparing to process information on the scale of a second but are abnormally disturbed by slightly asynchronous information on the millisecond scale In both cases the anomalies could explain the patients unusual experience of time The hypothesis in neurotypical patients is that small delays or asynchronies asynchronies are treated as irrelevant information and ignored and ignored whereas in patients suffering from schizophrenia they would disrupt the flow of time This hypothesis is tested with a new visual illusion
Detailed Description:
In the task two squares move at constant speed in a straight line towards each other When they collide and disappear neurotypical individuals perceive a gap between the two squares rather than contact This unexpected effect cannot be explained by a cognitive expectation since what is consciously expected is collision and contact It has been shown that it is sensory predictions which explain the illusion of space at the moment of contact Indeed a movement trajectory is accompanied by sensory predictions which help to anticipate the position of the moving object and of the contrast between the edges of the squares and the background At the moment of collision the contrast disappears and is processed as a prediction error If subjects do not have time to correct the error they see a gap as if the figure-ground contrast was still there Conversely when a rebound effect is introduced into the task the squares are moved in the opposite direction after the collision the illusion diminishes as if the rebound reinforces the top-down expectation of a collision
Perturbations will be introduced during the trajectory in the illusion task with and without rebound to test this hypothesis acceleration on a millisecond scale vs uniform speed Patients suffering from schizophrenia whose prediction mechanisms are fragile are expected to be abnormally sensitive to trajectory changes The experimental manipulations will help to compare sensory prediction illusion without rebound and top-down conscious prediction illusion with rebound
The protocol will also help to specify which types of prediction sensory or cognitive underlie patients sense patients sense of self In short the protocol is designed to improve the pathophysiological understanding of sense-of-self disorders in schizophrenia
Perturbations will be introduced during the trajectory in the illusion task with and without rebound to test this hypothesis acceleration on a millisecond scale vs uniform speed Patients suffering from schizophrenia whose prediction mechanisms are fragile are expected to be abnormally sensitive to trajectory changes The experimental manipulations will help to compare sensory prediction illusion without rebound and top-down conscious prediction illusion with rebound
The protocol will also help to specify which types of prediction sensory or cognitive underlie patients sense patients sense of self In short the protocol is designed to improve the pathophysiological understanding of sense-of-self disorders in schizophrenia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None