Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06362343
Status:
RECRUITING
Last Update Posted:
2024-04-12
First Post:
2024-04-09
Brief Title:
The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics Pharmacodynamics and Pharmacogenomics
Sponsor:
Peking Union Medical College Hospital
Organization:
Peking Union Medical College Hospital
Study Overview
Official Title:
The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics Pharmacodynamics and Pharmacogenomics
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Integrate pharmacokinetic-pharmacodynamic PK-PD modeling and pharmacogenomics techniques to develop a population PK-PD model aiming to explore monitoring and dose guidance schemes for Direct Oral Anticoagulants DOACs
2 Investigate the factors influencing PK-PD of DOACs in the pulmonary embolism population clarifying the correlation between genotype characteristics and clinical outcomes
3 Explore the correlation between drug concentrations coagulation indices and clinical outcomes of DOACs defining the indications for DOACs testing and the overall monitoring process
2 Investigate the factors influencing PK-PD of DOACs in the pulmonary embolism population clarifying the correlation between genotype characteristics and clinical outcomes
3 Explore the correlation between drug concentrations coagulation indices and clinical outcomes of DOACs defining the indications for DOACs testing and the overall monitoring process
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None