Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06368349
Status:
COMPLETED
Last Update Posted:
2024-04-18
First Post:
2024-04-11
Brief Title:
Persistent Lymphopenia in Liver Transplantation and Its Molecular Insights for Hepatocellular Carcinoma
Sponsor:
Chang Gung Memorial Hospital
Organization:
Chang Gung Memorial Hospital
Study Overview
Official Title:
Persistent Lymphopenia as a Prognostic Indicator in Liver Transplantation and Its Molecular Insights for Hepatocellular Carcinoma Recipients
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A total of 145 Liver transplantation LT recipients with hepatocellular carcinoma HCC were retrospectively enrolled at Kaohsiung Chang Gung Memorial Hospital between 2006 and 2019 Clinical records from 7 days before LT pre-LT to 1 year after LT post-LT were analysed In a prospective study from March 2022 to June 2023 20 lymphopenia and 25 non-lymphopenia HCC recipients were enrolled and a phenotypic analysis of peripheral blood lymphocytes was performed using multiparameter flow cytometry
Detailed Description:
A total of 145 Liver transplantation LT recipients with hepatocellular carcinoma HCC were retrospectively enrolled at Kaohsiung Chang Gung Memorial Hospital between 2006 and 2019 Clinical records from 7 days before LT pre-LT to 1 year after LT post-LT were analysed including overall survival recurrence-free survival association between clinical parameter with mortality patient characteristics by pre-lymphopenia and post-lymphopenia levels and lymphocyte status of HCC patients with usage of different immunosuppressants In prospective study from March 2022 to June 2023 20 lymphopenia and 25 non-lymphopenia HCC recipients were enrolled and a phenotypic analysis of peripheral blood lymphocytes was performed using multiparameter flow cytometry to identify the major immune cell subsets and the characteristics of patients in the prospective cohort between pre-LT lymphopenia and non-lymphopenia groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None