Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06367946
Status:
RECRUITING
Last Update Posted:
2024-04-16
First Post:
2024-04-11
Brief Title:
Mechanism Study of Ventilator-Induced Lung Injury in Elderly People
Sponsor:
Xinhua Hospital Shanghai Jiao Tong University School of Medicine
Organization:
Xinhua Hospital Shanghai Jiao Tong University School of Medicine
Study Overview
Official Title:
Mechanism Study Under the Role of Tissue Kallikrein-related Peptidase 8 KLK8-Induced Senescence of Pulmonary Vascular Endothelial Cells in Ventilator-induced Lung Injury in Elderly People
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age
2 We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelialepithelial damage age and duration of mechanical ventilation
2 We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelialepithelial damage age and duration of mechanical ventilation
Detailed Description:
1 We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age All clinical samples have been collected and tested uniformly Correlation analysis between KLK8 and age will be performed by using Statistical Package for the Social Sciences SPSS 220 software and P005 indicates a statistically significant difference The obtained clinical data should be recorded on survey forms and researchers should verify patient information by recording basic information such as age and gender
2 We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelialepithelial damage age and duration of mechanical ventilation All clinical samples have been collected and tested uniformly Correlation analysis between endothelialepithelial damage index age and duration of mechanical ventilation will be performed by using SPSS 220 software and P005 indicates a statistically significant difference The obtained clinical data should be recorded on survey forms and researchers should verify patient information by recording basic information such as age and gender
2 We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelialepithelial damage age and duration of mechanical ventilation All clinical samples have been collected and tested uniformly Correlation analysis between endothelialepithelial damage index age and duration of mechanical ventilation will be performed by using SPSS 220 software and P005 indicates a statistically significant difference The obtained clinical data should be recorded on survey forms and researchers should verify patient information by recording basic information such as age and gender
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None