Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06365086
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-15
First Post:
2024-04-05
Brief Title:
Targeting Personalized Brain States Reflecting Strong and Weak Corticospinal Tract Output in Real-time
Sponsor:
University of Texas at Austin
Organization:
University of Texas at Austin
Study Overview
Official Title:
Targeting Personalized Brain States Reflecting Strong and Weak Corticospinal Tract Output in Real-time
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Transcranial magnetic stimulation TMS interventions could feasibly strengthen residual corticospinal tract CST connections and enhance recovery of paretic hand function after stroke To maximize the therapeutic effects of such interventions they must be delivered during poststroke brain activity patterns during which TMS best activates the residual corticospinal tract and enhances neural transmission within it ie brain state-dependent TMS In this study the investigators will test the feasibility of real-time personalized brain state-dependent TMS in neurotypical adults
Participants will visit the laboratory for one day of testing Upon arrival participants will provide their informed consent afterwards they will complete eligibility screening The investigators will then place recording electrodes on the scalp using a swim-type cap and on the left first dorsal interosseous abductor pollicis brevis and extensor digitorum communis muscles After determining the location at which TMS best elicits muscle twitches in the left first dorsal interosseous the investigators will determine the lowest possible intensity at which TMS elicits muscle twitches at least half of the time in this muscle Then the investigators will deliver 6 blocks of 100 single TMS pulses while the participant rests quietly with their eyes open stimulation will be delivered at an intensity that is 20 greater than the lowest possible intensity at which TMS elicits muscle twitches at least half of the time Afterwards the investigators will use the muscle and brain activity recordings acquired during these 6 blocks to build a personalized mathematical model that identifies which patterns of brain activity correspond to the largest TMS-evoked muscle twitches The investigators will then use this model to detect the occurrence of these brain activity patterns in real-time when these patterns are detected single TMS pulses will be delivered Afterwards all recording electrodes will be removed participation will be complete and participants will leave the laboratory
The investigators will recruit a total of 16 neurotypical adults for this study
Participants will visit the laboratory for one day of testing Upon arrival participants will provide their informed consent afterwards they will complete eligibility screening The investigators will then place recording electrodes on the scalp using a swim-type cap and on the left first dorsal interosseous abductor pollicis brevis and extensor digitorum communis muscles After determining the location at which TMS best elicits muscle twitches in the left first dorsal interosseous the investigators will determine the lowest possible intensity at which TMS elicits muscle twitches at least half of the time in this muscle Then the investigators will deliver 6 blocks of 100 single TMS pulses while the participant rests quietly with their eyes open stimulation will be delivered at an intensity that is 20 greater than the lowest possible intensity at which TMS elicits muscle twitches at least half of the time Afterwards the investigators will use the muscle and brain activity recordings acquired during these 6 blocks to build a personalized mathematical model that identifies which patterns of brain activity correspond to the largest TMS-evoked muscle twitches The investigators will then use this model to detect the occurrence of these brain activity patterns in real-time when these patterns are detected single TMS pulses will be delivered Afterwards all recording electrodes will be removed participation will be complete and participants will leave the laboratory
The investigators will recruit a total of 16 neurotypical adults for this study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None