Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06361641
Status:
RECRUITING
Last Update Posted:
2024-06-12
First Post:
2024-03-12
Brief Title:
Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes
Sponsor:
University Hospital Angers
Organization:
University Hospital Angers
Study Overview
Official Title:
Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes-PHEMOP
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PHEMOP
Brief Summary:
Prospective study for functional and phenotypic characterization of monocytes in philadelphia-negative myeloproliferative neoplasms
Detailed Description:
Philadelphia-negative myeloproliferative neoplasms MPN are clonal disorders of the hematopoietic stem cell characterized by an excessive production of mature myeloid cells MPNs are characterized by the presence of somatic gain-of-function mutations present in more than 80 of cases and affecting JAK2 CALR or MPL genes These mutations lead to a constitutive activation of the JAK-STAT signaling pathway at the origin of cell proliferation
MPN include polycythemia vera PV essential thrombocythemia ET prefibrotic primary myelofibrosis pre-PMF and primary myelofibrosis PMF Despite the classification of MPNs into distinct subtypes based on clinical and pathological features the precise mechanisms underlying the phenotypic diversity within these disorders remain poorly understood One aspect that has received limited attention is the role of monocytes and macrophages key components of the innate immune system in MPN pathogenesis
Monocytes circulating precursors of tissue-resident macrophages play essential roles in inflammation immune surveillance and tissue repair Upon recruitment to tissues monocytes differentiate into macrophages with diverse phenotypes and functions influenced by local microenvironmental cues Macrophages in turn exhibit a spectrum of activation states ranging from pro-inflammatory M1 to anti-inflammatory or pro-repair M2 with implications for various physiological and pathological processes Recent studies have implicated monocytes and macrophages in the pathogenesis of MPNs Circulating monocytes in MPN patients display altered functional characteristics including dysregulated cytokine production and enhanced fibrotic potential Additionally monocytosis an elevated monocyte count has been identified as an adverse prognostic factor in MPNs particularly in PMF
Based on these observations investigator propose that monocytes and macrophages contribute to the phenotypic expression of MPNs and that distinct phenotypic and functional signatures of these cells may be associated with different MPN subtypes By leveraging available techniques for genetic and functional analysis study team aims to elucidate the role of monocytes and macrophages in MPN pathogenesis and identify potential biomarkers associated with disease phenotype and prognosis Through comprehensive characterization of these immune cell populations investigator seek to gain insights into the underlying mechanisms driving the heterogeneity of MPNs and identify novel therapeutic targets for precision medicine approaches
MPN include polycythemia vera PV essential thrombocythemia ET prefibrotic primary myelofibrosis pre-PMF and primary myelofibrosis PMF Despite the classification of MPNs into distinct subtypes based on clinical and pathological features the precise mechanisms underlying the phenotypic diversity within these disorders remain poorly understood One aspect that has received limited attention is the role of monocytes and macrophages key components of the innate immune system in MPN pathogenesis
Monocytes circulating precursors of tissue-resident macrophages play essential roles in inflammation immune surveillance and tissue repair Upon recruitment to tissues monocytes differentiate into macrophages with diverse phenotypes and functions influenced by local microenvironmental cues Macrophages in turn exhibit a spectrum of activation states ranging from pro-inflammatory M1 to anti-inflammatory or pro-repair M2 with implications for various physiological and pathological processes Recent studies have implicated monocytes and macrophages in the pathogenesis of MPNs Circulating monocytes in MPN patients display altered functional characteristics including dysregulated cytokine production and enhanced fibrotic potential Additionally monocytosis an elevated monocyte count has been identified as an adverse prognostic factor in MPNs particularly in PMF
Based on these observations investigator propose that monocytes and macrophages contribute to the phenotypic expression of MPNs and that distinct phenotypic and functional signatures of these cells may be associated with different MPN subtypes By leveraging available techniques for genetic and functional analysis study team aims to elucidate the role of monocytes and macrophages in MPN pathogenesis and identify potential biomarkers associated with disease phenotype and prognosis Through comprehensive characterization of these immune cell populations investigator seek to gain insights into the underlying mechanisms driving the heterogeneity of MPNs and identify novel therapeutic targets for precision medicine approaches
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| AO2721-44 | OTHER | ANSM | None |