Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06367595
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-29
First Post:
2024-02-20
Brief Title:
Effect of Intrathecal Magnesium Sulfate Versus Intravenous Magnesium Sulfate on Postoperative Pain After Abdominal Hysterectomy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Effect of Intrathecal Magnesium Sulfate Versus Intravenous Magnesium Sulfate on Postoperative Pain After Abdominal Hysterectomy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The present study aims to compare the effect of adding IV magnesium sulfate versus magnesium sulfate to intrathecal hyperbaric bupivacaine in total abdominal hysterectomy regarding the duration of postoperative analgesia hemodynamic stability and complications
Detailed Description:
Abdominal Hysterectomy AH is associated with an intense inflammatory response that can result in moderate to severe postoperative pain sometimes difficult to control
Postoperative pain can cause many complications such as restlessness increased sympathetic activity high blood pressure and tachycardia Opioids are effective analgesics however they produce unwanted side effects such as respiratory depression nausea and vomiting Nonopioid drugs can decrease opioid usage and dependency
Different adjuvants have been added to local anesthetics to increase the duration of the regional anesthesia decrease pain-relieving drugs and delay the onset of postoperative pain
According to numerous reports Magnesium sulfate has analgesic effects and lowers opioid consumption in many surgeries especially abdominal surgeries
The analgesic properties of magnesium are based on acting as a non-competitive antagonist of N-Methyl-D-Aspartate NMDA receptors in central nervous system and regulating the calcium influx into the cell These properties avoid the central sensitization mechanisms due to the stimulation of peripheral nociceptive nerves In the spinal cord magnesium sulfate decreases pain transmission by hyperpolarizing spinal interneurons via G-protein-mediated activation of potassium channels and by decreasing the release of the neurotransmitters substance P and glutamate from primary afferent terminals
Adequate postoperative pain relief can enhance recovery and increase patient satisfaction
Postoperative pain can cause many complications such as restlessness increased sympathetic activity high blood pressure and tachycardia Opioids are effective analgesics however they produce unwanted side effects such as respiratory depression nausea and vomiting Nonopioid drugs can decrease opioid usage and dependency
Different adjuvants have been added to local anesthetics to increase the duration of the regional anesthesia decrease pain-relieving drugs and delay the onset of postoperative pain
According to numerous reports Magnesium sulfate has analgesic effects and lowers opioid consumption in many surgeries especially abdominal surgeries
The analgesic properties of magnesium are based on acting as a non-competitive antagonist of N-Methyl-D-Aspartate NMDA receptors in central nervous system and regulating the calcium influx into the cell These properties avoid the central sensitization mechanisms due to the stimulation of peripheral nociceptive nerves In the spinal cord magnesium sulfate decreases pain transmission by hyperpolarizing spinal interneurons via G-protein-mediated activation of potassium channels and by decreasing the release of the neurotransmitters substance P and glutamate from primary afferent terminals
Adequate postoperative pain relief can enhance recovery and increase patient satisfaction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None