Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06363981
Status:
RECRUITING
Last Update Posted:
2024-04-15
First Post:
2024-04-09
Brief Title:
Multisite rTMS for Mood Cognitive Impairment and Other Symptoms of Depression
Sponsor:
Jakub Antczak
Organization:
Jagiellonian University
Study Overview
Official Title:
Multisite Repetitive Transcranial Magnetic Stimulation for Mood Cognitive Impairment Anhedonia and Disordered Sleep in Depressive Disorder
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Depressed mood is the main symptom of depression but other symptoms like cognitive impairment anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat rTMS is a relatively novel treatment option whose therapeutic potential is still investigated and optimized The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment anhedonia and sleep disorders in depression
Detailed Description:
Depression is one of the most common and disabling disorders affecting approximately three hundred million people worldwide Depressive mood is the main symptom but other symptoms like cognitive impairment anhedonia or sleep disorders contribute significantly to patients suffering decrease quality of life and may even lead to suicide attempt While modern pharmacotherapy can significantly improve symptoms in many patients still one third of patients remains drug-resistant Repetitive transcranial magnetic stimulation rTMS is a non-invasive method of inducing brain plasticity Stimulation over the left and right dorsolateral prefrontal cortex DLPFC and possibly over several other areas can improve mood Only few studies investigated the effect of rTMS on negative psychiatric symptoms such as anhedonia sleeplessness or cognitive impairment In these trials either the DLPFC or the dorsomedial prefrontal cortex dmPFC were stimulated and sometimes other areas such as the insular cortex The aim of this study is to investigate if a stimulation over both sites multi-site stimulation has better therapeutic potential for depressed mood cognitive impairment anhedonia and sleep disorders than stimulation over DLPFC alone and placebo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None