Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06368752
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-04-16
First Post:
2023-07-30
Brief Title:
The Role of Endogenous GIP in Glycosis Metabolism During Fasting
Sponsor:
Frederikke Koefoed-Hansen
Organization:
University Hospital Gentofte Copenhagen
Study Overview
Official Title:
GA-18 The Role of Endogenous GIP in Glycosis Metabolism During Fasting
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This research project aims to investigate the role of endogenous GIP during fasting With the infusion of a GIP receptor antagonist GIP3-30NH2 is it possible to selectively remove the effect of endogenous GIP and thus describe its effects by comparing it with what happens during a saline infusion
Detailed Description:
This research project investigates the effects endogenous GIP has in the body of healthy overweight people Two trial days will be held The participant will receive intravenous infusion of either GIP3-30NH2 800 pmolkgmin or placebo saline in a randomized order After 20 minutes GIP3-30NH2 is expected to have maximum effect On time of 180 minutes an ad libitum meal is served which is consumed during continued infusion When the participant is comfortably full the infusion is turned off and the trial day ends During the day the participant assesses and notes on standardized VAS schedules current appetite satiety nausea fatigue malaise and thirst Blood pressure and heart rate are measured every 30 minutes throughout the trial day and blood samples are taken In total there will be drawn ten blood samples between intervals of 15 to 30 min Three times along the way the activity in the brown adipose tissue is measured with a thermal camera temperature measurements over the skin on the chest and the resting metabolic rate is determined with indirect calorimetry inhaled and exhaled air is captured by breathing under a large plastic bell
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None