Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06357507
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-16
First Post:
2024-04-05
Brief Title:
Molecular Characterization of Moraxella Catarrhalis From Pneumonic Children at Pediatric Assiut University Hospital
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Molecular Characterization of Moraxella Catarrhalis Isolates From Pneumonic Children at Pediatric Assiut University Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Mcatarrhalis
Brief Summary:
moraxella catarrhalis is responsible for respiratory tract infection in children and adults with streptococcus pneumonia and haemophilus influenzaMoraxella catarrhalis is gram negative diplococci non-motile and non spore bearing bacteria Until 1995 it was considered as a non pathogenic respiratory tract floraThis bacteria is an important pathogen and a common cause of both upper and lower respiratory tract infections pneumonia sinusitis and conjunctivitis in infants children and in elderly patients In adults M catarrhalis also causes chronic obstructive pulmonary disease COPD and pneumonia However it is associated with a number of respiratory infections affecting both children and adults including laryngitis bronchitis and pneumonia
Detailed Description:
This institution is polymicrobial community with other pathogens such as Streptococcus pneumoniae and Haemophilus influenza Sethi and Murphy 2008 The pathogenicity of M catarrhalis is mediated by several virulence genes including the ubiquitous surface protein genes A1 uspA1 and A2 uspA2 which encode virulence factors that promote colonization and successful host infections Bernhard S et al2012Bacterium was first isolated in 1896 it was considered to be a harmless commensal of the upper respiratory tract for a long period of time The bacterium rapidly colonizes the nasopharynx soon after birth asymptomatically Blakeway et al 2017
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None