Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06357273
Status:
COMPLETED
Last Update Posted:
2024-04-10
First Post:
2024-04-04
Brief Title:
The Effect of White Tea Consumption on Obesity
Sponsor:
Recep Tayyip Erdogan University
Organization:
Recep Tayyip Erdogan University
Study Overview
Official Title:
White Tea Consumption Alleviates on Body Composition Oxidative Stress Appetite Hormones Inflammation and Lipids in Obese Patients
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity is an increasing global public health issue In general tea consumption have been shown to offer benefit to obese patients However the potential of white tea WT to treat and protect from the adverse effects of obesity have not been addressed so far The aim of this study was to examine the efficacy and impact WT consumption highest in catechins on levels of anthropometric and biochemical values in obese patients
Detailed Description:
Obesity is the increase in body weight above the normal level as a result of excessive fat accumulation This condition is a chronic metabolic disease that increases the risk of long-term medical complications The prevalence of obesity is an increasing global public health problem Numerous conditions such as excessive and malnutrition lack of physical activity hormonal factors genetic and psychological factors and medicine use are effective in the formation of obesity Obesity is associated with many diseases such as cardiovascular diseases type 2 diabetes hypertension and dyslipidemia
Since the mechanical load and myocardial metabolism increase in obesity oxygen consumption also increases Therefore there is an increase in the formation of oxygen radicals ROS caused by mitochondrial respiration Oxidative stress and ROS stimulate pro-inflammatory cytokine release ROS attack macromolecules such as DNA proteins lipids Macromolecular damage results in cellular damage and death Damages caused by ROS are repaired by antioxidant defense systems It has been suggested that inflammatory markers such as ghrelin leptin adiponectin interleukins matrix metalloproteinases tumor necrosis factor are associated with insulin resistance in obese patients These substances are effective on food intake energy balance insulin activity lipid and glucose metabolism angiogenesis and vascular structuring and blood pressure in the body
Many drugs have been used to treat obesity Orlistat is a widely used drug to treat this disease It reversibly inhibits gastric and pancreatic lipases Inactivation of lipases prevents the hydrolysis of triglycerides Metformin a dimethylbiguanide inhibits the mitochondrial complex-I which leads to adenosine 5-monophosphate activated protein kinase AMPK activation By affecting the AMPK level it provides the translocation of the glucose transporter 4 protein independently of insulin and regulates the blood glucose level Clinicians often prescribe it to achieve weight loss However they have evinced serious adverse effects including headache cardiovascular diseases and depression which restrict their use
In recent years one of the fastest growing fields in the treatment of obesity is the use of natural herbal products and many studies have proven the use of herbal products to be effective and safe Especially tea is reported to have anti-obesity anti-diabetes anti-inflammatory and hypolipidaemic actions
Tea is produced from the leaves of the Camellia sinensis plant which belongs to the Theaceae family and is one of the most consumed beverages after water in many societies In general four types of tea are produced from the tea plant WT differs from other teas in that only the buds and young leaves of the plant are used WT has important benefits for human health with its high content of catechins and derivatives as well as other tea components
In the literature searches no clinical research has been found on the effect of WT on obesity which is richer than other tea varieties in terms of antioxidant properties and produced with less processing This study aimed to determine the effect of WT consumption on obesity and the relationship between anthropometric and biochemical values of WT consumption in obese individuals
Since the mechanical load and myocardial metabolism increase in obesity oxygen consumption also increases Therefore there is an increase in the formation of oxygen radicals ROS caused by mitochondrial respiration Oxidative stress and ROS stimulate pro-inflammatory cytokine release ROS attack macromolecules such as DNA proteins lipids Macromolecular damage results in cellular damage and death Damages caused by ROS are repaired by antioxidant defense systems It has been suggested that inflammatory markers such as ghrelin leptin adiponectin interleukins matrix metalloproteinases tumor necrosis factor are associated with insulin resistance in obese patients These substances are effective on food intake energy balance insulin activity lipid and glucose metabolism angiogenesis and vascular structuring and blood pressure in the body
Many drugs have been used to treat obesity Orlistat is a widely used drug to treat this disease It reversibly inhibits gastric and pancreatic lipases Inactivation of lipases prevents the hydrolysis of triglycerides Metformin a dimethylbiguanide inhibits the mitochondrial complex-I which leads to adenosine 5-monophosphate activated protein kinase AMPK activation By affecting the AMPK level it provides the translocation of the glucose transporter 4 protein independently of insulin and regulates the blood glucose level Clinicians often prescribe it to achieve weight loss However they have evinced serious adverse effects including headache cardiovascular diseases and depression which restrict their use
In recent years one of the fastest growing fields in the treatment of obesity is the use of natural herbal products and many studies have proven the use of herbal products to be effective and safe Especially tea is reported to have anti-obesity anti-diabetes anti-inflammatory and hypolipidaemic actions
Tea is produced from the leaves of the Camellia sinensis plant which belongs to the Theaceae family and is one of the most consumed beverages after water in many societies In general four types of tea are produced from the tea plant WT differs from other teas in that only the buds and young leaves of the plant are used WT has important benefits for human health with its high content of catechins and derivatives as well as other tea components
In the literature searches no clinical research has been found on the effect of WT on obesity which is richer than other tea varieties in terms of antioxidant properties and produced with less processing This study aimed to determine the effect of WT consumption on obesity and the relationship between anthropometric and biochemical values of WT consumption in obese individuals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None