Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06355232
Status:
RECRUITING
Last Update Posted:
2024-04-09
First Post:
2024-04-07
Brief Title:
Covid-19 and Influenza Oral Vaccine Study
Sponsor:
Vaxine Pty Ltd
Organization:
Vaxine Pty Ltd
Study Overview
Official Title:
A Binded Randomised Controlled Cross-over Trial to Assess the Safety and Efficacy of Mucosal Covid-19 and Influenza Vaccines
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the current study is to assess the effectiveness of protein-based COVID-19 or influenza vaccines when given individually or together via oral sublingual mucosal route instead of intramuscular delivery The comparator will be a seasonal influenza vaccine which will also be administered with Advax-CpG adjuvant via the oral route This study will use a cross-over design and everyone in the study will over a space of about 4 months receive both the COVID-19 and influenza vaccines
Detailed Description:
The SARS-CoV-2 outbreak has caused millions of deaths globally It has a particularly high mortality rate in elderly people and those with chronic disease SARS-COV-2 vaccines remain a key priority to help fight the current pandemic as they help reduce symptomatic infection and disease severity However vaccine immunity starts to wane as early as 3 months following the most recent immunisation This rapidly waning vaccine immunity is a particular problem for the newer Omicron variants Spikogen vaccine is an Advax-CpG552 adjuvanted recombinant protein vaccine that was shown to significantly reduce infection and serious disease in a pivotal Phase 3 trial in 16876 participants who received two intramuscular doses 3 weeks apart SpikoGen vaccine was licensed for use in the Middle East as a primary vaccine course in adults in October 2021 Eight million doses of SpikoGen vaccine have subsequently been supplied to date A booster study confirmed the safety and immunogenicity of SpikoGen vaccine when given as a third dose intramuscular booster to adult participants who previously received two doses of either inactivated viral vaccine adenoviral vector vaccine mRNA or recombinant protein vaccine While COVID-19 vaccines such as SpikoGen vaccine have been shown to reduce the incidence of severe SARS-CoV-2 infection disease they have less effect on SARS-CoV-2 infection or transmission This is because intramuscular vaccines largely work by increasing antibody and T cell levels within the body whereas what is needed to prevent infection and transmission is mucosal immunity which means increasing immunity at the body surfaces where the virus initially gets access to the body namely the mucosal surfaces of the nose and upper respiratory tract To induce mucosal immunity normally requires immune cells at these respiratory tract surfaces to be exposed to the relevant viral antigen which requires the vaccine to be applied to these surfaces in such a way as to trigger an appropriate immune responseThe current study is based on the finding that an adjuvanted protein-based COVID-19 vaccine SpikoGen when given as 2 sublingual doses 2 weeks apart in monkeys that had previously received a primary course of 2 intramuscular doses of the same vaccine was safe and well tolerated and induced robust protection against challenge with the heterologous Omicron BA5 virus The monkeys that received the sublingual boost also showed reduced nasal virus shedding additional details in the Investigator Brochure This suggests an oral sublingual COVID-19 vaccine may also help block virus transmission Similarly mice that received sublingual inactivated influenza vaccine with Advax-CpG adjuvant have demonstrated robust protection against an otherwise lethal influenza infection The purpose of the current study is to assess the effectiveness of protein-based COVID-19 or influenza vaccines when given individually or together via oral sublingual mucosal route instead of intramuscular delivery The comparator will be a seasonal influenza vaccine which will also be administered with Advax-CpG adjuvant via the oral route This study will use a cross-over design and everyone in the study will over a space of about 4 months receive both the COVID-19 and influenza vaccines
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None