Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06355947
Status:
COMPLETED
Last Update Posted:
2024-04-10
First Post:
2024-03-26
Brief Title:
Cycling and Treadmill With Dual Task for Parkinsons Disease Improvement
Sponsor:
Chang Gung University
Organization:
Chang Gung University
Study Overview
Official Title:
Cycling Induced Motor Cortex Plasticity and Functional Improvement -the Dual Task Evaluation Model for Parkinson Disease
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Motor impairment in lower extremities is common in individuals with Parkinson disease PD Development sensitive test for early motor deviations is important Conventional walking test cannot induce the PD related motor impairments such as freezing of gait Therefore finding a safe substitute test to induce PD related motor impairments is important
Studies showed that working memory related dual task walking was a sensitive test for PD However the optimal cognitive test needs to be clarified Studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking Therefore dual task cycling test is potential to be a safe and sensitive testing model
Studies showed that exercise could improve cognitive function and induce brain plasticity Dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall Whether the added cognitive task could improve to detriment brain plasticity in PD should be investigated Transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity
The purpose of this three-year project is to develop PD-sensitive The purposes of the first year are to translate the dual task walking test to dual task cycling test and to establish the reliability of the dual task cycling test
The purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between PD and healthy control people
The purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with PD on motor cortex plasticity dual task performance and ambulation ability
Studies showed that working memory related dual task walking was a sensitive test for PD However the optimal cognitive test needs to be clarified Studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking Therefore dual task cycling test is potential to be a safe and sensitive testing model
Studies showed that exercise could improve cognitive function and induce brain plasticity Dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall Whether the added cognitive task could improve to detriment brain plasticity in PD should be investigated Transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity
The purpose of this three-year project is to develop PD-sensitive The purposes of the first year are to translate the dual task walking test to dual task cycling test and to establish the reliability of the dual task cycling test
The purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between PD and healthy control people
The purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with PD on motor cortex plasticity dual task performance and ambulation ability
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None