Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06353464
Status:
RECRUITING
Last Update Posted:
2024-04-09
First Post:
2024-02-15
Brief Title:
A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
Sponsor:
Drexel University
Organization:
Drexel University
Study Overview
Official Title:
A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OPBIM
Brief Summary:
This study will examine a potential relationship between family history of obesity that is whether people with at least one parent who had obesity in adulthood compared to people with two parents who did not have obesity in adulthood and the ability of protein intake to curb further intake of food
Detailed Description:
1 Abstract of the study A positive energy balance greater intake than expenditure can explain weight gain and when protracted leads to overweight and obesity The major question addressed in this proposal is if the timing of activation of specific regions of the brain is predictive of excessive food intake Functional near infra-red spectroscopy fNIR seldom used in human eating studies provides data similar to functional magnetic resonance imaging fMRI but allows for measurement of brain activation during food consumption The investigators pilot fNIR data reveal that varying patterns of regional PFC activation are associated with loss of control over eating and that only 60 of individuals respond to acute protein intake with a reduction in food intake Using fNIR and an acute protein challenge the investigator will assess the effect of family history of obesity in humans on the satiation response to protein and concomitant activation of the prefrontal cortex PFC It is hypothesized that activation of the human medial PFC before the lateral PFC will result in greater intake of palatable food in those subjects with a proneness to obesity and that these subjects will be less sensitive to the satiety-inducing effects of a protein preload These results should provide an innovative and useful method for assessing risk for developing obesity and usefulness of preventative interventions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None