Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06354972
Status:
COMPLETED
Last Update Posted:
2024-04-09
First Post:
2024-04-03
Brief Title:
Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration
Sponsor:
University of Turin Italy
Organization:
University of Turin Italy
Study Overview
Official Title:
Impact of the Senescence Associated Secretory Phenotype in the Gingival Crevicular Fluid on the Outcomes of Periodontal Regeneration
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objectives To test the impact of clinical inflammation and molecular expression profile senescence-associated secretory phenotype SASP in the gingival crevicular fluid GCF on the outcomes of minimally-invasive periodontal regeneration in intra-bony defects
Methods Sites associated with intrabony defects 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included Pre-operatively GCF was sampled for inflammatory biomarker analysis related to SASP interleukin IL-1β IL-6 and IL-12 matrix-metalloproteinases MMP-8 and -9 Correlation analyses and logistic regression models were performed to assess the impact of predictors on clinical and radiographic outcomes
Methods Sites associated with intrabony defects 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included Pre-operatively GCF was sampled for inflammatory biomarker analysis related to SASP interleukin IL-1β IL-6 and IL-12 matrix-metalloproteinases MMP-8 and -9 Correlation analyses and logistic regression models were performed to assess the impact of predictors on clinical and radiographic outcomes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None