Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2025-12-17 @ 1:05 PM
Study NCT ID:
NCT06354504
Status:
None
Last Update Posted:
2024-04-09 00:00:00
First Post:
2024-03-07 00:00:00
Brief Title:
Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment
Sponsor:
Akdeniz University
Organization:
Akdeniz University
Study Overview
Official Title:
Gingival Crevicular Fluid (GCF) Bactericidal/Permeability-increasing Protein (BPI) and Interleukin (IL)-1beta in Periodontitis Patients: Non-surgical Periodontal Treatment Effects
Status:
None
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Bactericidal/permeability-increasing proteins (BPI) specific and powerful effect against Gram negative bacteria and their LPSs is completely observable in biological fluids such as plasma, serum, and whole blood.
Objective: It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta (IL-1 β) levels in gingival fluid before and after non-surgical periodontal treatment (NSPT)in patients with periodontal disease.
Method: Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study. Before NSPT, the clinical parameters of plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAS), bleeding on probing (BOP) were measured. The gingival fluid samples were taken using the paper strip method. The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment. ELISA method was used for the analysis of the samples
Objective: It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta (IL-1 β) levels in gingival fluid before and after non-surgical periodontal treatment (NSPT)in patients with periodontal disease.
Method: Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study. Before NSPT, the clinical parameters of plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAS), bleeding on probing (BOP) were measured. The gingival fluid samples were taken using the paper strip method. The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment. ELISA method was used for the analysis of the samples
Detailed Description:
Bactericidalpermeability-increasing proteins BPI specific and powerful effect against Gram negative bacteria and their LPSs is completely observable in biological fluids such as plasma serum and whole blood
Objective It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta IL-1 β levels in gingival fluid before and after non-surgical periodontal treatment NSPTin patients with periodontal disease
Method Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study Before NSPT the clinical parameters of plaque index PI gingival index GI probing depth PD clinical attachment level CAS bleeding on probing BOP were measured The gingival fluid samples were taken using the paper strip method The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment ELISA method was used for the analysis of the samples
Objective It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta IL-1 β levels in gingival fluid before and after non-surgical periodontal treatment NSPTin patients with periodontal disease
Method Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study Before NSPT the clinical parameters of plaque index PI gingival index GI probing depth PD clinical attachment level CAS bleeding on probing BOP were measured The gingival fluid samples were taken using the paper strip method The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment ELISA method was used for the analysis of the samples
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None