Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06353412
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-09
First Post:
2024-03-20
Brief Title:
Current Treatment Methods of Idiopathic Intracranial Hypertension
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Evaluation of the Current Treatment Methods of Idiopathic Intracranial Hypertension
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aim of the study
1 to determine the response to each treatment plan
2 to determine when to choose specific treatment method
3 to determine complication of each type of treatment method
1 to determine the response to each treatment plan
2 to determine when to choose specific treatment method
3 to determine complication of each type of treatment method
Detailed Description:
Idiopathic intracranial hypertension IIH is caused by an elevation of intracranial pressure ICP The condition mainly affects obese young women of childbearing age
In a recent study in the United Kingdom University of Kentucky urokinase the estimated annual incidence was 47 which represents a growth of 108 in 14 years and parallels the growth of obesity prevalence
The combination of raised intracranial pressure without hydrocephalus or mass lesion normal cerebrospinal fluid CSF composition and where no underlying aetiology is found are accepted criteria for the diagnosis of IIH
The two most prominent symptoms of IIH are progressive visual deterioration and chronic headache although additional symptoms including cranial nerve palsies cognitive deficits tinnitus and olfactory dysfunction are frequently also part of the clinical presentation While the visual dysfunction is known to largely result from a pressure-induced papilledema the origin of the IIH-related headache is less clear and therapeutic approaches are less investigated
The conventional treatment for IIH involves weight loss steroids diuretics and serial lumbar punctures and surgical treatment
Surgical intervention should be conducted as soon as medical treatment fails It is not acceptable to delay the intervention for patient with sever visual deterioration Therefore surgery is indicated once visual loss continues despite optimum medical therapy
Medical treatment with acetazolamide and serial lumbar punctures represent the initial management in such cases preserving surgery to non-responding cases and those who cannot tolerate medical treatment
Surgical treatment include lumboperitoneal shunt insertion navigation guided ventriculo-peritoneal shunt endovascular stenting of sinuses in cases of sinus thrombosis and stenosis
In a recent study in the United Kingdom University of Kentucky urokinase the estimated annual incidence was 47 which represents a growth of 108 in 14 years and parallels the growth of obesity prevalence
The combination of raised intracranial pressure without hydrocephalus or mass lesion normal cerebrospinal fluid CSF composition and where no underlying aetiology is found are accepted criteria for the diagnosis of IIH
The two most prominent symptoms of IIH are progressive visual deterioration and chronic headache although additional symptoms including cranial nerve palsies cognitive deficits tinnitus and olfactory dysfunction are frequently also part of the clinical presentation While the visual dysfunction is known to largely result from a pressure-induced papilledema the origin of the IIH-related headache is less clear and therapeutic approaches are less investigated
The conventional treatment for IIH involves weight loss steroids diuretics and serial lumbar punctures and surgical treatment
Surgical intervention should be conducted as soon as medical treatment fails It is not acceptable to delay the intervention for patient with sever visual deterioration Therefore surgery is indicated once visual loss continues despite optimum medical therapy
Medical treatment with acetazolamide and serial lumbar punctures represent the initial management in such cases preserving surgery to non-responding cases and those who cannot tolerate medical treatment
Surgical treatment include lumboperitoneal shunt insertion navigation guided ventriculo-peritoneal shunt endovascular stenting of sinuses in cases of sinus thrombosis and stenosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None