Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06355102
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-04-09
First Post:
2024-03-12
Brief Title:
The Development of Tinnitus in Patients With SSNHL Insights From fMRI and Metabolomics
Sponsor:
The First Affiliated Hospital with Nanjing Medical University
Organization:
The First Affiliated Hospital with Nanjing Medical University
Study Overview
Official Title:
The Generation and Chronicity of Tinnitus in Patients With Sudden Sensorineural Hearing Loss Insights From fMRI and Serum Metabolomics Analysis
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to investigate the factors and mechanisms underlying tinnitus generation and chronification in patients with sudden sensorineural hearing loss SSNHL The main questions it aims to answer are
What are the peripheral and central influencing factors that contribute to tinnitus in patients with SSNHL
Can serum metabolic biomarkers be identified to predict and monitor tinnitus prognosis in these patients
Participants in this study will include patients with SSNHL and tinnitus patients with SSNHL without tinnitus and healthy subjects They will be asked to undergo a series of assessments including audiological tests vestibular function examinations and functional magnetic resonance imaging fMRI Additionally blood samples will be collected for metabolomics analysis
Investigators will compare the brain functional states and serum metabolite profiles of patients with SSNHL and tinnitus to those without tinnitus Morever tinnitus symptom characteristics audiological outcomes and brain functional states will be assessed during time
What are the peripheral and central influencing factors that contribute to tinnitus in patients with SSNHL
Can serum metabolic biomarkers be identified to predict and monitor tinnitus prognosis in these patients
Participants in this study will include patients with SSNHL and tinnitus patients with SSNHL without tinnitus and healthy subjects They will be asked to undergo a series of assessments including audiological tests vestibular function examinations and functional magnetic resonance imaging fMRI Additionally blood samples will be collected for metabolomics analysis
Investigators will compare the brain functional states and serum metabolite profiles of patients with SSNHL and tinnitus to those without tinnitus Morever tinnitus symptom characteristics audiological outcomes and brain functional states will be assessed during time
Detailed Description:
The incidence rate of tinnitus is very high globally and shows an increasing trend year by year Sudden sensorineural hearing loss SSNHL a prevalent otolaryngological emergency often coincides with tinnitus among its patient population This condition can significantly impact individuals interpersonal relationships work performance and daily functioning ultimately leading to a diminished quality of life and even psychological disturbances such as anxiety and depression Consequently it is imperative to expore the mechanisms underlying the emergence and chronicity of tinnitus following SSNHL and to devise targeted intervention strategies aimed at preventing the chronicity of tinnitus
This study aims to enroll 30 patients with SSNHL accompanied by tinnitus 30 patients with SSNHL without tinnitus and 30 healthy subjects Investigators will record general demographic information tinnitus symptom characteristics audiological examinations vestibular function tests and other information for each group during the acute phase of SSNHL onset Using functional magnetic resonance imaging fMRI investigators will compare the brain functional states of patients with SSNHL accompanied by tinnitus and those without tinnitus during the acute phase to investigate the peripheral influencing factors and central mechanisms of tinnitus production Additionally investigators will conduct metabolomics analysis to compare the serum metabolite profiles of these two patient groups to identify serum metabolic biomarkers and prognostic biomarkers for tinnitus in patients with SSNHL accompanied by tinnitus Furthermore this study will conduct follow-up assessments on the subjects at 1 month 3 months and 6 months after the onset of SSNHL reviewing changes in their symptom characteristics audiological examinations and fMRI At 6 months after the onset patients will be divided into a tinnitus recovery group and a tinnitus non-recovery group based on their tinnitus recovery status Investigators will compare the general demographic characteristics audiological examinations and brain functional MRI findings between the two groups to explore the role and mechanisms of brain plasticity changes in the recovery or chronicity of tinnitus in patients with SSNHL
This study aims to enroll 30 patients with SSNHL accompanied by tinnitus 30 patients with SSNHL without tinnitus and 30 healthy subjects Investigators will record general demographic information tinnitus symptom characteristics audiological examinations vestibular function tests and other information for each group during the acute phase of SSNHL onset Using functional magnetic resonance imaging fMRI investigators will compare the brain functional states of patients with SSNHL accompanied by tinnitus and those without tinnitus during the acute phase to investigate the peripheral influencing factors and central mechanisms of tinnitus production Additionally investigators will conduct metabolomics analysis to compare the serum metabolite profiles of these two patient groups to identify serum metabolic biomarkers and prognostic biomarkers for tinnitus in patients with SSNHL accompanied by tinnitus Furthermore this study will conduct follow-up assessments on the subjects at 1 month 3 months and 6 months after the onset of SSNHL reviewing changes in their symptom characteristics audiological examinations and fMRI At 6 months after the onset patients will be divided into a tinnitus recovery group and a tinnitus non-recovery group based on their tinnitus recovery status Investigators will compare the general demographic characteristics audiological examinations and brain functional MRI findings between the two groups to explore the role and mechanisms of brain plasticity changes in the recovery or chronicity of tinnitus in patients with SSNHL
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None