Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06354348
Status:
COMPLETED
Last Update Posted:
2024-04-09
First Post:
2024-03-30
Brief Title:
Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy
Sponsor:
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Organization:
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Study Overview
Official Title:
Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy A Cross-sectional Case-control Study
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators aimed to evaluate long-term sarcopenia in patients with total and distal gastrectomy by measuring the anterior thigh muscle with USG which is a more specific and easy method
Detailed Description:
Sarcopenia was found to be significantly increased in patients who underwent total proximal and distal gastrectomy compared to those who did not undergo gastrectomy in the long term
To date very few studies have investigated the development of sarcopenia in the long term after gastrectomy In these studies sarcopenia was usually assessed using BIA and DEXA Muscle thickness measured by ultrasound has high sensitivity and specificity in determining regional muscle mass
Patients who underwent totaln20 and subtotal gastrectomyn35 and patients who did not undergo gastrectomyn35 were included in the study
Ultrasonographic measurements Anterior thigh muscle thickness of the dominant side was measured at the mid-point between the anterior superior iliac spine and the upper border of the patella Transverse measurements were obtained between the outer fascia of rectus femoris muscle and the periosteum of femur Sonographic thigh adjustment ratio STAR was calculated by dividing the anterior thigh muscle thickness mm by BMI
Functional evaluations Grip strength was measured with an electronic hand dynamometer Three repeat measurements were performed from the dominant side and the maximum value was taken for the analyses Chair stand test CST was performed while participants were asked to stand up and sit down from a chair - without arm rest for five times as quick as possible with their arms crossed over their chests Three measurements were performed and median values were taken for the analyses
Diagnosis of sarcopenia The ISarcoPRM algorithm was used whereby the diagnosis of sarcopenia was established if low muscle mass ie STAR values 14 for males and 10 for females was combined with low grip strength 32 kg males and 19 kg females andor increased CST time 12 sec
To date very few studies have investigated the development of sarcopenia in the long term after gastrectomy In these studies sarcopenia was usually assessed using BIA and DEXA Muscle thickness measured by ultrasound has high sensitivity and specificity in determining regional muscle mass
Patients who underwent totaln20 and subtotal gastrectomyn35 and patients who did not undergo gastrectomyn35 were included in the study
Ultrasonographic measurements Anterior thigh muscle thickness of the dominant side was measured at the mid-point between the anterior superior iliac spine and the upper border of the patella Transverse measurements were obtained between the outer fascia of rectus femoris muscle and the periosteum of femur Sonographic thigh adjustment ratio STAR was calculated by dividing the anterior thigh muscle thickness mm by BMI
Functional evaluations Grip strength was measured with an electronic hand dynamometer Three repeat measurements were performed from the dominant side and the maximum value was taken for the analyses Chair stand test CST was performed while participants were asked to stand up and sit down from a chair - without arm rest for five times as quick as possible with their arms crossed over their chests Three measurements were performed and median values were taken for the analyses
Diagnosis of sarcopenia The ISarcoPRM algorithm was used whereby the diagnosis of sarcopenia was established if low muscle mass ie STAR values 14 for males and 10 for females was combined with low grip strength 32 kg males and 19 kg females andor increased CST time 12 sec
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None