Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06353789
Status:
RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-04-02
Brief Title:
Adolescent Dysmenorrhoea as a Risk Factor for Chronic Pain Clinical Cohort Study
Sponsor:
University of Oxford
Organization:
University of Oxford
Study Overview
Official Title:
Understanding the Role of Adolescent Dysmenorrhoea as a Risk Factor for the Transition to Chronic Pain Clinical Cohort Study
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RoADPain
Brief Summary:
This study aims to understand whether changes in a variety of body systems which are seen in adult women with period pain are also seen in adolescents in the first few years of having periods This information will help to understand 1 how quickly any changes occur informing clinical practice and 2 how period pain might lead to other types of chronic pain potentially allowing development of preventative strategies
Detailed Description:
Chronic pain is defined as pain that lasts for more than 3 months It is really common affecting up to 30 of people worldwide with impacts on all areas of life Chronic pain is difficult to treat once it has developed Therefore understanding which people might be at risk of developing chronic pain and protecting them from it starting would be a really positive step forward
It is known that women are more likely to develop almost all types of chronic pain than men This sex difference in chronic pain starts to be seen after puberty suggesting that changes happening at this time may be contributing to this increased risk One important change that happens at this time is periods starting Despite periods often being very painful period pain has traditionally been dismissed as normal and something girls must learn to live with However in adult women with period pain many differences are seen across a range of body systems when compared to women without period pain These include increased sensitivity to pain increased sensitivity of the bladder bowel and womb altered brain structure and function and altered responses to stress Similar changes to those seen with period pain can be seen in other chronic pain conditions It is not known whether these changes are caused by repeated or continuous pain or if they are part of the reason why chronic pain develops or a combination of both
The RoADPain Clinical Study aims to see whether the differences in other body systems described above in adult women with period pain are also seen in girls in the first few years of having periods The investigators will combine detailed questionnaire data with tests of the function of a variety of systems including nerve function stress response and brain imaging No study treatment or intervention will be given It is envisaged that this information will help to understand 1 how quickly any changes occur informing clinical practice and 2 how period pain might lead to other types of chronic pain potentially allowing development of preventative strategies
It is known that women are more likely to develop almost all types of chronic pain than men This sex difference in chronic pain starts to be seen after puberty suggesting that changes happening at this time may be contributing to this increased risk One important change that happens at this time is periods starting Despite periods often being very painful period pain has traditionally been dismissed as normal and something girls must learn to live with However in adult women with period pain many differences are seen across a range of body systems when compared to women without period pain These include increased sensitivity to pain increased sensitivity of the bladder bowel and womb altered brain structure and function and altered responses to stress Similar changes to those seen with period pain can be seen in other chronic pain conditions It is not known whether these changes are caused by repeated or continuous pain or if they are part of the reason why chronic pain develops or a combination of both
The RoADPain Clinical Study aims to see whether the differences in other body systems described above in adult women with period pain are also seen in girls in the first few years of having periods The investigators will combine detailed questionnaire data with tests of the function of a variety of systems including nerve function stress response and brain imaging No study treatment or intervention will be given It is envisaged that this information will help to understand 1 how quickly any changes occur informing clinical practice and 2 how period pain might lead to other types of chronic pain potentially allowing development of preventative strategies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None